Table 7 Top hallmark and GO biological processes pathways enriched for genes closest to DNAm probe sites in cis-mQTLs in endometrium and blood

Endometrial mQTLs

Go intracellular signal transduction

1.92E-29

5.50E-26

Go regulation of multicellular organismal development

2.48E-29

5.50E-26

Go regulation of transport

5.10E-28

7.54E-25

Go regulation of cell differentiation

1.29E-27

1.43E-24

Go regulation of cell proliferation

2.73E-26

2.42E-23

Go neurogenesis

4.37E-26

3.23E-23

Go regulation of cell death

5.66E-26

3.58E-23

Go locomotion

1.16E-25

6.41E-23

Go positive regulation of molecular function

3.00E-25

1.48E-22

Go regulation of transcription from rna polymerase ii promoter

9.31E-25

4.13E-22

Hallmark uv response dn

9.77E-13

4.88E-11

Hallmark oestrogen response early

1.94E-10

4.84E-09

Hallmark epithelial mesenchymal transition

6.07E-07

8.57E-06

Hallmark complement

6.86E-07

8.57E-06

Hallmark androgen response

1.68E-06

9.69E-06

Hallmark hypoxia

1.94E-06

9.69E-06

Hallmark allograft rejection

1.94E-06

9.69E-06

Hallmark il2 stat5 signalling

1.94E-06

9.69E-06

Hallmark p53 pathway

1.94E-06

9.69E-06

Hallmark myogenesis

1.94E-06

9.69E-06

Blood mQTLs

Go intracellular signal transduction

9.02e-46

4.00e-42

Go positive regulation of molecular function

2.00e-39

4.44e-36

Go neurogenesis

3.12e-39

4.62e-36

Go regulation of multicellular organismal development

2.39e-38

2.29e-35

Go regulation of hydrolase activity

2.58e-38

2.29e-35

Go regulation of intracellular signal transduction

1.23e-37

9.08e-35

Go positive regulation of catalytic activity

3.82e-37

2.12e-34

Go tissue development

3.91e-37

2.12e-34

Go locomotion

4.78e-37

2.12e-34

Go regulation of cell differentiation

4.79e-37

2.12e-34

Hallmark uv response dn

5.31e-16

2.66e-14

Hallmark oestrogen response early

1.74e-14

4.35e-13

Hallmark epithelial mesenchymal transition

3.49e-10

5.25e-09

Hallmark complement

4.20e-10

5.25e-09

Hallmark oestrogen response late

4.04e-09

4.04e-08

Hallmark myogenesis

1.20e-08

1.00e-07

Hallmark mitotic spindle

3.48e-08

2.49e-07

Hallmark p53 pathway

9.80e-08

6.12e-07

Hallmark apical junction

2.32e-07

1.22e-06

Hallmark tnfa signalling via nfkb

2.68e-07

1.22e-06