Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases

Clinical Epigenetics

Table 6 Results of the SMR analysis conducted using blood mQTLs and summary statistics from an endometriosis meta-analysis

CHR	DNAm probe Site ID	Closest TSS gene name	Probe bp	Top SNP	Top SNP bp	A1	b_SMR	p_SMR	p_HET
2	cg02584498	GREB1	11,674,057	rs77294520	11,660,955	C	0.149038	1.01E-11	0.009952231
2	cg10849854	GREB1	11,674,557	rs77294520	11,660,955	C	0.250387	4.40E-10	0.000121199
4	cg10360906	KDR	56,023,751	rs11936364	56,019,253	T	− 0.075528	2.43E-09	0.000696251
4	cg01777861	KDR	56,023,843	rs7696256	56,023,747	G	− 0.096417	3.38E-09	0.000267448
4	cg09978860	KDR	56,023,921	rs11936364	56,019,253	T	− 0.0974429	3.70E-09	0.000221536
1	cg25011003	WNT4	22,470,341	rs55938609	22,470,451	C	0.280871	4.71E-09	0.181277
4	cg16572876	KDR	56,024,045	rs11936364	56,019,253	T	− 0.144697	1.17E-08	0.000408871
4	cg20092376	KDR	56,023,423	rs6837695	56,015,840	T	− 0.148622	1.17E-08	0.000631242
4	cg07123701	KDR	56,024,434	rs11936364	56,019,253	T	− 0.151501	1.29E-08	0.000349096
2	cg16908938	GREB1	11,728,079	rs59129126	11,728,388	C	0.0779192	1.34E-08	0.04232295
2	cg07314298	Metazoa _SRP	11,723,111	rs59129126	11,728,388	C	0.105449	1.88E-08	0.1823231
1	cg15582954	WNT4	22,470,343	rs55938609	22,470,451	C	0.361317	7.96E-08	0.3437667
11	cg26197155	C11orf46	30,344,725	rs12271187	30,319,259	A	− 0.112429	1.71E-07	0.8086896

ISSN: 1868-7083