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Fig. 8 | Clinical Epigenetics

Fig. 8

From: RFX1 downregulation contributes to TLR4 overexpression in CD14+ monocytes via epigenetic mechanisms in coronary artery disease

Fig. 8

Enrichments of DNMT1, HDAC1, and SUV39H1 in the TLR4 promoter in CD14+ monocytes. a–d The relative enrichment levels of RFX1 (a), DNMT1 (b), HDAC1 (c), and SUV39H1 (d) in TLR4 promoter with RFX1 binding region were measured by ChIP-qPCR in CAD CD14+ monocytes. e–h The enrichments of RFX1 (e), DNMT1 (f), HDAC1 (g), and SUV39H1 (h) in TLR4 promoter with RFX1 binding region were measured by ChIP-qPCR in the LDL-treated CD14+ monocytes. The fold changes were shown between LDL treatment with control group. All values are the average of at least three biological replicates, and the data shown are the means ± SDs. *P < 0.05; **P < 0.01 relative to control

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