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Table 4 The 15 most significant DMRs associated with alcohol out of 90 significant DMRs (adjusted for recruitment center, age at recruitment, menopausal status, and level of different lymphocyte subtypes)

From: Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

  DMRs characteristics CpG characteristics Fused lasso
Associated genes Gene regions hg19coord Sites1 q DMR 2 β min, DMR 3 β max, DMR 3 Overlap4 β FL 5
A1 GSDMD TSS1500, TSS200, 5′UTR, 1stExon chr8:144635260-144636462 9 4.7E−14 0.0060 0.020   
A2    chr6:31650735-31651362 21 1.8E−13 0.0049 0.018 2/2, 2/2 0.390
A3 TRIM4 Body, 1stExon, 5′UTR, TSS200, TSS1500 chr7:99516603-99517509 14 3.0E−06 − 0.0007 0.018   
A4 RGL3 Body chr19:11517079-11517436 5 3.3E−06 0.0041 0.020   
A5 COL9A3 TSS1500 chr20:61446962-61447992 32 4.8E−06 − 0.0004 − 0.012 4/4 − 1.027
A6 ADAM32 TSS1500, TSS200, 1stExon, 5′UTR, Body chr8:38964500-38965492 10 1.3E−04 0.0019 0.014   
A7 C21orf56 5′UTR, 1stExon, TSS1500 chr21:47604052-47605174 8 1.5E−04 0.0191 0.032   
A8    chr2:118616155-118616576 5 1.9E−04 0.0143 0.019 5/7 0.514
A9 LTB4R2, LTB4R, CIDEB Body, 1stExon, TSS1500, 5′UTR, TSS200 chr14:24780404-24780926 10 2.3E−04 − 0.0031 − 0.012 9/9 − 0.474
A10 PTDSS2 Body chr11:457256-457304 3 3.0E−04 0.0044 0.011   
A11 SMC1B, RIBC2 Body, TSS1500, 1stExon, TSS200, 5′UTR chr22:45808669-45810043 16 3.0E−04 0.0009 0.019 4/4, 3/3 0.332
A12    chr10:72013286-72013397 2 8.4E−04 − 0.0087 − 0.014   
A13 TRAF3 Body chr14:103366987-103367858 5 1.4E−03 − 0.0044 0.013   
A14 C22orf27 TSS1500, TSS200, body chr22:31317764-31318546 12 1.4E−03 0.0016 0.015 4/4, 2/2 0.641
A15 S100A13, S100A1 5′UTR, 1stExon, TSS1500, TSS200 chr1:153599479-153600156 8 3.0E−03 0.0076 0.019   
  1. 1Number of sites located in DMRs significant for alcohol
  2. 2Minimum alcohol q values of sites located in the DMRs (FDR correction)
  3. 3Absolute minimum and maximum of alcohol coefficient of sites located in the DMRs, for 1 standard deviation of alcohol intake (SD = 11.8)
  4. 4Number of sites from the FL region overlapping the DMR/number of sites in the FL region, appears twice if two FL regions are included in the DMR
  5. 5Alcohol changes for an increase of 1 standard deviation of methylation levels of sites located in the FL region or average of alcohol change if two FL regions are included in a DMR