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Table 4 The 15 most significant DMRs associated with alcohol out of 90 significant DMRs (adjusted for recruitment center, age at recruitment, menopausal status, and level of different lymphocyte subtypes)

From: Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

 

DMRs characteristics

CpG characteristics

Fused lasso

Associated genes

Gene regions

hg19coord

Sites1

q DMR 2

β min, DMR 3

β max, DMR 3

Overlap4

β FL 5

A1

GSDMD

TSS1500, TSS200, 5′UTR, 1stExon

chr8:144635260-144636462

9

4.7E−14

0.0060

0.020

  

A2

  

chr6:31650735-31651362

21

1.8E−13

0.0049

0.018

2/2, 2/2

0.390

A3

TRIM4

Body, 1stExon, 5′UTR, TSS200, TSS1500

chr7:99516603-99517509

14

3.0E−06

− 0.0007

0.018

  

A4

RGL3

Body

chr19:11517079-11517436

5

3.3E−06

0.0041

0.020

  

A5

COL9A3

TSS1500

chr20:61446962-61447992

32

4.8E−06

− 0.0004

− 0.012

4/4

− 1.027

A6

ADAM32

TSS1500, TSS200, 1stExon, 5′UTR, Body

chr8:38964500-38965492

10

1.3E−04

0.0019

0.014

  

A7

C21orf56

5′UTR, 1stExon, TSS1500

chr21:47604052-47605174

8

1.5E−04

0.0191

0.032

  

A8

  

chr2:118616155-118616576

5

1.9E−04

0.0143

0.019

5/7

0.514

A9

LTB4R2, LTB4R, CIDEB

Body, 1stExon, TSS1500, 5′UTR, TSS200

chr14:24780404-24780926

10

2.3E−04

− 0.0031

− 0.012

9/9

− 0.474

A10

PTDSS2

Body

chr11:457256-457304

3

3.0E−04

0.0044

0.011

  

A11

SMC1B, RIBC2

Body, TSS1500, 1stExon, TSS200, 5′UTR

chr22:45808669-45810043

16

3.0E−04

0.0009

0.019

4/4, 3/3

0.332

A12

  

chr10:72013286-72013397

2

8.4E−04

− 0.0087

− 0.014

  

A13

TRAF3

Body

chr14:103366987-103367858

5

1.4E−03

− 0.0044

0.013

  

A14

C22orf27

TSS1500, TSS200, body

chr22:31317764-31318546

12

1.4E−03

0.0016

0.015

4/4, 2/2

0.641

A15

S100A13, S100A1

5′UTR, 1stExon, TSS1500, TSS200

chr1:153599479-153600156

8

3.0E−03

0.0076

0.019

  
  1. 1Number of sites located in DMRs significant for alcohol
  2. 2Minimum alcohol q values of sites located in the DMRs (FDR correction)
  3. 3Absolute minimum and maximum of alcohol coefficient of sites located in the DMRs, for 1 standard deviation of alcohol intake (SD = 11.8)
  4. 4Number of sites from the FL region overlapping the DMR/number of sites in the FL region, appears twice if two FL regions are included in the DMR
  5. 5Alcohol changes for an increase of 1 standard deviation of methylation levels of sites located in the FL region or average of alcohol change if two FL regions are included in a DMR
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Clinical Epigenetics

ISSN: 1868-7083

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