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Table 3 The 15 most significant DMRs associated with dietary folate out of 24 significant DMRs (adjusted for recruitment center, age at recruitment, menopausal status, and level of different lymphocyte subtypes)

From: Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

  DMR characteristics CpG characteristics Fused lasso
Associated genes Gene regions hg19coord Sites1 q DMR 2 β min, DMR 3 β max, DMR 3 Overlap4 β FL 5
F1 HOXA5,HOXA6 1stExon, 5′UTR, TSS200, TSS1500, 3′UTR, body chr7:27183133-27185512 49 1.3E−13 0.0002 0.019   
F2 GDF7 Body chr2:20869434-20871401 8 1.4E−08 − 0.016 − 0.033 7/8 − 0.0029
F3 CYP1A1 TSS1500 chr15:75018731-75019376 13 2.4E−05 0.0004 0.014   
F4 PRSS50 Body, 1stExon, 5′UTR, TSS200, TSS1500 chr3:46759096-46759698 9 2.4E−04 − 0.002 − 0.020 4/4 − 0.0069
F5 HOXA4 1stExon, 5′UTR, TSS200, TSS1500 chr7:27170241-27171154 14 5.8E−04 − 0.005 − 0.016   
F6 SYNGAP1 Body chr6:33401192-33401542 6 1.0E−03 0.004 0.008   
F7 ZNF833 TSS1500, TSS200, body chr19:11784514-11785337 13 1.1E−03 − 0.002 − 0.012   
F8 LAMB2 1stExon, 5′UTR, TSS200, TSS1500 chr3:49170496-49170849 6 3.1E−03 − 0.008 − 0.012   
F9 GPR19 5′UTR, 1stExon, TSS200, TSS1500 chr12:12848977-12849588 9 3.7E−03 0.001 0.023 6/7 0.0076
F10 MTMR15 TSS1500, TSS200, 5′UTR, 1stExon chr15:31195612-31196075 7 4.0E−03 − 0.003 − 0.017   
F11 KCNE1 5′UTR, 1stExon, TSS200, TSS1500 chr21:35831871-35832364 8 4.2E−03 0.007 0.019   
F12 TNXB Body chr6:32054659-32055474 20 7.2E−03 0.0002 − 0.013   
F13 TERT Body chr5:1269992-1270152 3 7.2E−03 0.008 0.011   
F14 C2orf27A 5′UTR chr2:132481613-132481826 2 1.7E−02 0.010 0.031   
F15 ANKRD44 Body chr2:198029141-198029332 3 2.1E−02 − 0.005 − 0.018   
  1. 1Number of sites located in DMRs significant for dietary folate
  2. 2Minimum dietary folate q values of sites located in the DMRs (FDR correction)
  3. 3Absolute minimum and maximum of dietary folate coefficient of sites located in the DMRs, for 1 standard deviation of log-transformed diet folate (SD = 0.346)
  4. 4Number of sites from the FL region overlapping the DMR/number of sites in the FL region
  5. 5Dietary folate changes for an increase of 1 standard deviation of methylation levels of sites located in the FL region