Table 3 The 15 most significant DMRs associated with dietary folate out of 24 significant DMRs (adjusted for recruitment center, age at recruitment, menopausal status, and level of different lymphocyte subtypes)
DMR characteristics | CpG characteristics | Fused lasso | |||||||
|---|---|---|---|---|---|---|---|---|---|
Associated genes | Gene regions | hg19coord | Sites1 | q DMR 2 | β min, DMR 3 | β max, DMR 3 | Overlap4 | β FL 5 | |
F1 | HOXA5,HOXA6 | 1stExon, 5′UTR, TSS200, TSS1500, 3′UTR, body | chr7:27183133-27185512 | 49 | 1.3E−13 | 0.0002 | 0.019 | ||
F2 | GDF7 | Body | chr2:20869434-20871401 | 8 | 1.4E−08 | − 0.016 | − 0.033 | 7/8 | − 0.0029 |
F3 | CYP1A1 | TSS1500 | chr15:75018731-75019376 | 13 | 2.4E−05 | 0.0004 | 0.014 | ||
F4 | PRSS50 | Body, 1stExon, 5′UTR, TSS200, TSS1500 | chr3:46759096-46759698 | 9 | 2.4E−04 | − 0.002 | − 0.020 | 4/4 | − 0.0069 |
F5 | HOXA4 | 1stExon, 5′UTR, TSS200, TSS1500 | chr7:27170241-27171154 | 14 | 5.8E−04 | − 0.005 | − 0.016 | ||
F6 | SYNGAP1 | Body | chr6:33401192-33401542 | 6 | 1.0E−03 | 0.004 | 0.008 | ||
F7 | ZNF833 | TSS1500, TSS200, body | chr19:11784514-11785337 | 13 | 1.1E−03 | − 0.002 | − 0.012 | ||
F8 | LAMB2 | 1stExon, 5′UTR, TSS200, TSS1500 | chr3:49170496-49170849 | 6 | 3.1E−03 | − 0.008 | − 0.012 | ||
F9 | GPR19 | 5′UTR, 1stExon, TSS200, TSS1500 | chr12:12848977-12849588 | 9 | 3.7E−03 | 0.001 | 0.023 | 6/7 | 0.0076 |
F10 | MTMR15 | TSS1500, TSS200, 5′UTR, 1stExon | chr15:31195612-31196075 | 7 | 4.0E−03 | − 0.003 | − 0.017 | ||
F11 | KCNE1 | 5′UTR, 1stExon, TSS200, TSS1500 | chr21:35831871-35832364 | 8 | 4.2E−03 | 0.007 | 0.019 | ||
F12 | TNXB | Body | chr6:32054659-32055474 | 20 | 7.2E−03 | 0.0002 | − 0.013 | ||
F13 | TERT | Body | chr5:1269992-1270152 | 3 | 7.2E−03 | 0.008 | 0.011 | ||
F14 | C2orf27A | 5′UTR | chr2:132481613-132481826 | 2 | 1.7E−02 | 0.010 | 0.031 | ||
F15 | ANKRD44 | Body | chr2:198029141-198029332 | 3 | 2.1E−02 | − 0.005 | − 0.018 | ||