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Table 2 Identification of multi-probe regions associated with Braak stage

From: Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

A

Position

Gene name

Probes in DMR

Putative region P

Sidak-corrected P

Probes in DMR

8:41519307-41519400

ANK1

2

8.51E−08

6.50E−04

cg05066959

cg11823178

10:63809072-63809171

ARID5B

6

1.64E−07

1.18E−03

cg00928816

cg07520810

cg14789659

cg16389209

cg16401465

cg20746552

B

Position

Gene name

Probes in DHR

Putative region P

Sidak-corrected P

Probes in DHR

16:745662-745766

FBXL16

4

3.75E−08

1.55E−04

cg01003448

cg01195246

cg02958327

cg07482202

C

Position

Gene name

Probes in DUR

Putative region P

Sidak-corrected P

Probes in DUR

14:105619633-105619702

JAG2

2

1.70E−09

1.75E−05

cg13617301

cg19893664

10:63809072-63809171

ARID5B

6

3.46E−08

2.49E−04

cg00928816

cg07520810

cg14789659

cg16389209

cg16401465

cg20746552

2:3714277-3714316

ALLC

2

8.84E−08

1.61E−03

cg04307702

cg27089736

  1. Using Comb-p, we identified spatially correlated P values within a 500-bp sliding window [17]. DMRs are shown in (A), DHRs are shown in (B), and DURs are shown in (C). Shown are regions with a Sidak-corrected P value < 0.05
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Clinical Epigenetics

ISSN: 1868-7083

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