Fig. 1
Braak-associated differentially modified positions identified in the EC in BS data in this study are consistent with those identified in previous analyses of AD brain. a There was a consistent direction of effect for the top 100 Braak-associated differentially modified positions identified in the EC in BS data in the “discovery cohort” when compared with the same probes in a previously published dataset of Braak-associated differentially modified positions in the EC from BS data (“validation cohort 1”) (sign test P = 2.04 × 10−4), with the effect sizes highly correlated between studies (r = 0.591, P = 8.92 × 10−11). b Similarly, there was a consistent direction of effect for the previously published top 100 Braak-associated differentially modified positions in the EC in BS data (“validation cohort 1”) when compared with the same probes in the current study (sign test P = 2.04 × 10−4), with the effect sizes highly correlated between studies (r = 0.550, P = 2.95 × 10−9)