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Table 3 Main epigenetic modifications in autoimmune thyroid diseases (AITDs) and type 1 diabetes (T1D)

From: The emerging role of epigenetics in human autoimmune disorders

Autoimmune disease

DNA methylation

Histone modification

miRNA

AITD

↑ T cells [133,134,135]

↓ H3, H4 acetylation

IFN-α enhances H3K4 methylation

[24, 134, 136, 137]

↓ miR-155-5p, ↓ miR-146a-5p, ↓ miR-125a-3p

↓ miR-197a-3p

Fibroblasts: ↑ miR-21-5p [138,139,140,141]

T1D

↑ T cell

↑ FOXP3 [150, 156, 157]

↑ H3 acetylation [159]

↑ miR-510

↓ miR-342, ↓ miR-191 [160]

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Clinical Epigenetics

ISSN: 1868-7083

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