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Fig. 3 | Clinical Epigenetics

Fig. 3

From: A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients

Fig. 3

Validation of the differently methylated CpGs by pyrosequencing. a Validation results in the discovery cohort (DC, n = 24)). The array data were replicated in LEF1/ LOC641519 and HOXA5 genes, with a significant higher methylation in non-responders patients vs. responder patients (p < 0.05) and FERD3L, TRIP, and CHL1 genes, with a significantly higher methylation in responder patients vs. non-responder patients (p < 0.05). The CDKL2, EVC2, and TLX3 genes showed a trend for significance (p ≥ 0.05). b Validation results in the validation cohort (VC, n = 30). Methylation data from the 450K array were only replicated for FERD3L gene. Values were statistically different when compared non-responder vs. responder group showing low methylation in non-responder patients (p = 0.0087). The TRIP10 gene showed a non-significant trend towards a high methylation in responder group compared to non-responder group (p = 0.19)

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Clinical Epigenetics

ISSN: 1868-7083

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