Fig. 8From: Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2Schematic representation of the working mechanism of AC1NOD4Q. By binding to the 36G46A sequence in the HOTAIR5′ domain, ADQ weakens the recruitment and binding abilities of EZH2 and strongly inhibits the H3K27-mediated tri-methylation of the NLK promoter, thereby restoring its expressionBack to article page