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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2

Fig. 6

Computational analysis of significantly dysregulated mRNAs revealed that ADQ is involved in tumor migration and metastasis. a MRNA microarrays were performed to identify differentially expressed genes in cells treated with DMSO or ADQ. b, c GO biology process and KEGG pathway enrichment analyses were performed, which indicated that the anti-cancer effects of ADQ may involve the repression of cell migration and metastasis. d, e The wound healing assay revealed that cell migratory activities were significantly reduced after treatment with ADQ. f, g ADQ treatment decreased the number of invaded cells, as indicated by the transwell assay. h ADQ treatment inhibited the β-catenin signaling pathway. The protein levels of nuclear β-catenin were significantly decreased in ADQ-treated cells

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Clinical Epigenetics

ISSN: 1868-7083

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