Skip to main content
Fig. 5 | Clinical Epigenetics

Fig. 5

From: Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2

Fig. 5

Structure-activity relationship analysis to elucidate the critical ADQ residues responsible for the inhibitory binding activity of HOTAIR and EZH2. a NLK luciferase activity was measured in LN229, U87, and U87 EGFRvIII glioma cells and in MDA-MB-231 breast cancer cells. b, c HOTAIR expression and NLK mRNA levels were detected after treatment with several structural analogs of ADQ in U87 cells

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us