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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Fig. 5

Principal component analysis of DNA methylation profiles of iPSC-derived HPCs with and without co-culture. The DNA methylation profiles of iHPCs (d20; donor 1 and 2) and iPSC-derived HPCs from Nishizawa et al. [14] are closely related to those of iHPCs that were further cultured for 2 weeks with or without stromal support. Additional stromal support (iHPC on MSCs, iMSCs, and TCP, respectively) did not enhance further commitment toward the hematopoietic lineage

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