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Table 5 Differential mean methylation of candidate genes in buccal cell DNA of children after maternal antenatal CBT or TAU

From: Exploring the effect of antenatal depression treatment on children’s epigenetic profiles: findings from a pilot randomized controlled trial

Gene Δß 95%CI P
NR3C1 0.004 −0.004 to 0.011 0.32
NR3C1 Promoter 0.002 −0.010 to 0.011 0.65
SLC6A4 0.013 −0.007 to 0.035 0.09
OXTR 0.008 −4.7e-05 to 1.6e-02 0.04
NR3C2 0.002 −0.005 to 0.009 0.6
MEST 0.013 0.003 to 0.024 0.02
MEG3 0.012 0.00004 to 0.023 0.04
IFG2 0.005 −0.014 to 0.028 0.65
HSD11B1 0.004 −0.0123 to 0.019 0.61
HSD11B2 0.003 −0.003 to 0.010 0.29
H19 0.019 0.003 to 0.041 0.03
CRHR1 0.013 −0.0003 to 0.027 0.06
CRHR2 0.019 0.002 to 0.032 0.02
CRHRBP -0.003 −0.033 to 0.033 0.93
CRH 0.001 −0.014 to 0.015 0.98
BDNF 0.001 −0.005 to 0.008 0.38
FKBP5 0.006 −0.0003 to 0.0139 0.051
  1. Δß = mean ß (TAU) - mean ß (CBT)
  2. CBT cognitive behavioral therapy, TAU treatment as usual