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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Exploring the effect of antenatal depression treatment on children’s epigenetic profiles: findings from a pilot randomized controlled trial

Fig. 3

Principal component analysis results of the variation in the HM850 methylation data. Principal component analysis revealed birth weight as the major contributor to variation in the dataset with intervention status as the fifth largest contributor to variation in buccal cell DNA methylation profiles. a Scree plot generated with M values for 770,668 probes on the HM850 array. Variance is shown on the y-axis, principal components are shown on the x-axis. b Heatmap showing correlation coefficients, direction of correlations, and p values (bracketed) between principal components and various clinical parameters. Shaded boxes indicate correlations between principal components and clinical parameters (set at p ≤ 0.1)

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