Fig. 2

Epigenome-wide association results on tooth mobility. a Epigenome-wide association results, where the green dotted line shows the epigenome-wide significance threshold (8.00e−06). There are 58 epigenome-wide significant associations with tooth mobility, showing positive (red) and negative (blue) correlation with tooth mobility. b The percentage of each genetic, shared environmental, and unique environmental factor contribution to the variance in methylation levels at the 58 CpG sites. Pink (A, heritability), green (C, common environment), and blue (E, unique environment) bars represent genetic, shared environmental, and unique environmental effects, respectively. Three CpGs denoted by “asterisk” are located in or near to genes that also showed exon expression levels with a nominally significant association with tooth mobility