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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta

Fig. 4

DNA methylation in the promoter region of the LEPR gene. a A schematic representation of the LEPR gene, including the CpG islands in the promoter region. b The methylation pattern in the LEPR promoter on the fetal and maternal sides of third-trimester placental biopsies from the control group. c The % methylation level in the LEPR promoter region from third-trimester placenta. DNA was extracted from third-trimester placental biopsies (on the fetal and maternal sides) in the control and obese women. After bisulfite treatment, the methylation level was determined by pyrosequencing. The data are quoted as the mean ± SEM. Statistical significance was assessed in a Friedman test

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Clinical Epigenetics

ISSN: 1868-7083

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