Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

Table 2 Significantly differentially methylated CpG probes in AMD RPE cells with FDR < 20% also showing a mean methylation difference between AMD and normal RPE cells of 10% minimum (FDR < 0.2, Δβ ≥ 0.1 (10%))

Probe ID	Gene	Adjusted p value	Δβ	Chromosome	CpG position	Accession reference	Probe location
cg18486102	FAIM2	1.08E−12	0.20	12	50297777	NM_012306	TSS200
cg18934822	SKI	1.18E−09	0.11	1	2191402	NM_003036	Body
cg23169512		2.08E−08	0.33	15	60290666		Intragenic
cg22508626	GTF2H4	7.03E−07	0.11	6	30879905	NM_001517	Body
cg01560972	RIC3	2.03E−06	0.33	11	8190837	NM_024557	TSS1500
cg04838987	EDEM2	3.98E−06	0.18	20	33734406	NM_001145025	Body
cg11241206	BDNF	4.44E−06	0.30	11	27723128	NM_001143813	TSS1500
cg26347887	EIF2AK3	5.16E−06	0.28	2	88927196	NM_004836	TSS200

TSS transcription start site, 5′UTR 5′-untranslated region, 3′-UTR 3′-untranslated region, Body gene body, Intragenic intragenic region

ISSN: 1868-7083