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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

Fig. 6

Gene expression of SKI, GTF2H4, TNXB, and EIF2AK3 and in human donor RPE samples. Relative mRNA quantification of SKI (a), GTF2H4 (b), TNXB (c), and EIF2AK3 (d) using RT-qPCR in AMD (n = 4) compared to normal (n = 3) human donor samples. Significant reduction in SKI (p = 0.0235) (a), GTF2H4 (p = 0.0174) (b), TNXB (p = 0.05) (c), and EIF2AK3 (p = 0.011) (d) was present in AMD (*p ≤ 0.05). All statistical analysis was performed using an unpaired Student’s t test

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