Clinical Epigenetics

Table 4 Loss of epigenetic mark immunoreactivity among different cell types in young adult mouse hippocampal dentate gyrus

From: DNA methylation and histone post-translational modification stability in post-mortem brain tissue

		Nuclear morphology
Epigenetic modification	Observed change (time point)	Large round	Intermediate	Small round	Small long/irregular	Endothelial/smooth muscle
5mC	72 h	Minimal
5hmC	72 h
5fC	72 h
5caC	72 h	Minimal
H3K4me3	72 h				Minimal	Minimal
H3K9me2, K9me3	72 h	Minimal			Minimal
H3K27me2	72 h	Moderate
H3K27me3	72 h	Minimal			Minimal	Minimal
H3K36me3	72 h				Minimal
H3K9ac	48 h	Moderate			Minimal
H3K14ac^A	72 h	Minimal				Minimal
H3K27ac	72 h	Minimal			Minimal
H4K5ac	48 h	Moderate
H4K12ac	48 h	Moderate
H4K16ac	48 h	n/a
Total H3	48 h	Minimal	Minimal
Total H4	72 h	Minimal	Minimal		Minimal

^A Large nuclei were not positively stained at 0 h
A blank cell represents no change

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ISSN: 1868-7083

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