From: DNA methylation and histone post-translational modification stability in post-mortem brain tissue
 | Nuclear morphology | |||||
---|---|---|---|---|---|---|
Epigenetic modification | Observed change (time point) | Large round | Intermediate | Small round | Small irregular/longer | Endothelial/smooth muscle |
5mC | 72 h | Minimal | Minimal | Minimal |  |  |
5hmC | 72 h |  |  | Minimal |  |  |
5fC | 72 h |  |  |  |  |  |
5caC | 72 h | n/a |  |  |  |  |
H3K4me3 | 72 h | Minimal |  |  | Minimal | Minimal |
H3K9me2, K9me3 | 72 h | Minimal |  |  | Minimal |  |
H3K27me2 | 72 h | Minimal |  |  |  |  |
H3K27me3 | 72 h | Minimal |  |  | Minimal |  |
H3K36me3 | 72 h |  |  |  |  | Minimal |
H3K9ac | 48 h | Moderate |  |  |  |  |
H3K14acA | 72 h | n/a | Minimal | Minimal | Minimal |  |
H3K27ac | 72 h | Moderate | Minimal | Moderate |  |  |
H4K5ac | 48 h | Moderate | Minimal |  | Minimal |  |
H4K12ac | 48 h | Minimal |  |  | Minimal |  |
H4K16ac | 48 h | Minimal |  |  |  |  |
Total H3 | 48 h | Minimal | Minimal | Minimal | Minimal | Minimal |
Total H4 | 72 h |  |  |  | Minimal |  |