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Table 3 Loss of epigenetic mark immunoreactivity among different cell types in newborn pig temporal/parietal cortices

From: DNA methylation and histone post-translational modification stability in post-mortem brain tissue

  Nuclear morphology
Epigenetic modification Observed change (time point) Large round Intermediate Small round Small irregular/longer Endothelial/smooth muscle
5mC 72 h Minimal Minimal Minimal   
5hmC 72 h    Minimal   
5fC 72 h      
5caC 72 h n/a     
H3K4me3 72 h Minimal    Minimal Minimal
H3K9me2,
K9me3
72 h Minimal    Minimal  
H3K27me2 72 h Minimal     
H3K27me3 72 h Minimal    Minimal  
H3K36me3 72 h      Minimal
H3K9ac 48 h Moderate     
H3K14acA 72 h n/a Minimal Minimal Minimal  
H3K27ac 72 h Moderate Minimal Moderate   
H4K5ac 48 h Moderate Minimal   Minimal  
H4K12ac 48 h Minimal    Minimal  
H4K16ac 48 h Minimal     
Total H3 48 h Minimal Minimal Minimal Minimal Minimal
Total H4 72 h     Minimal  
  1. ALarge nuclei were not positively stained at 0 h
  2. A blank cell represents no change