Fig. 2

Methylation levels of the top 11 most significant CpGs across the investigated three time points, i.e., M0 (before starting a metformin therapy), M10h (10 h after the first metformin intake, before the second tablet), and M7d (time point after 7 days of metformin administration), together with their associated genes. Box plots depict median, maximum, minimum, 25th percentile, and 75th percentile. Dots beyond the bounds of the whiskers represent outliers. * and ** denote significance levels 0.05 and 0.01 respectively