From: The role and mechanisms of action of microRNAs in cancer drug resistance
MiRNA | Cancer type | Corresponding drug | Targets | References |
---|---|---|---|---|
- Let-7b | Breast | −/TAM | ER-α36 | [35] |
Ovarian | +/Taxanes | IMP-1 | [82] | |
- Let-7c | NSCLC | −/CDDP | ABCC2, BCL-XL | [57] |
- Let-7e | Ovarian | −/CDDP | EZH2, CCND1 | [194] |
- 9 | Ovarian | −/CDDP | BRCA1 | [83] |
- 10b | Colorectal | +/5-FU | BIM | [73] |
- 15a/16 | Breast | −/TAM | BCL-2 (BCL2) | [167] |
- 15b | Lung | +/CDDP | PEBP4 | [64] |
- 17-5p | Lung | −/PTX | Beclin1 | [195] |
MCL | +/Topotecan | PHIPP2 | [196] | |
Breast | −/Taxol | NCOA3 | [197] | |
- 20a | Colorectal | +/5-FU,L-OHP, Teniposide | BNIP2 | [74] |
Breast | −/mutidrug | MAPK1 | [198] | |
- 21 | Ovarian | +/CDDP | PDCD4 | [88] |
Gastric | +/Trastuzumab | PTEN | [108] | |
Pancreas | +/GEM | FasL | [172] | |
Colorectal | +/5-FU | hMSH2 | [72] | |
- 23a | Colorectal | +/5-FU | APAF-1 | [75] |
- 25 | Gastric | +/CDDP | FOXO3a | [199] |
- 26a/b | HCC | +/DOX | ULK1 | [200] |
- 26b | HCC | −/DOX | TAK1, TAB3 | [201] |
- 27a | Bladder | +/CDDP | SLC7A11 | [202] |
Lung | +/CDDP | RKIP | [65] | |
- 30a | Cervical,Breast, HCC | −/CDDP | Beclin1 | [112] |
- 30c | Breast | −/DOX | YWHAZ | [203] |
- 30e | CML | −/Imatinib | ABL | [103] |
- 31 | NSCLC | +/CDDP | ABCB9 | [58] |
Ovarian | −/PTX | MET | [98] | |
- 34a | Breast | −/DOX | NOTCH1 | [204] |
Lung | −/CDDP | PEBP4 | [67] | |
Breast | +/Docetaxel | BCL-2, CCND1 | [37] | |
Prostate | −/PTX | SIRT1, BCL-2 | [102] | |
Colorectal | −/5-FU | c-Kit | [77] | |
- 34c | Lung | +/PTX | BMF | [205] |
- 92b | NSCLC | +/CDDP | PTEN | [68] |
- 93 | Ovarian | +/CDDP | PTEN | [89] |
- 96 | Colorectal | −/5-FU | XIAP | [76] |
Breast, HCC | −/CDDP | RAD51, REV1 | [43] | |
- 100 | Pancreatic | −/CDDP | FGFR3 | [114] |
Lung | −/Docetaxel | PIK1 | [206] | |
- 101 | Ovarian | +/DOX | EZH2 | [207] |
- 103 | Leukemia | −/CDDP | COP1 | [208] |
- 106a | Lung | +/CDDP | ABCA1 | [63] |
Ovarian | +/CDDP | PDCD4 | [90] | |
Ovarian | −/CDDP | Mcl-1 | [92] | |
- 122 | Colon | −/5-FU | PKM2 | [209] |
- 125b | HCC | −/5-FU | Hexokinase II | [38] |
Breast | +/5-FU | E2F3 | [210] | |
APL | +/DOX | Bak1 | [107] | |
- 126 | NSCLC | −/DOX, VCR | VEGFA | [175] |
- 130a | Ovarian | −/CDDP | XIAP | [93] |
HCC | +/CDDP | RUNX3 | [46] | |
Ovarian | +/CDDP | PTEN | [91] | |
- 130b | Ovarian | −/CDDP, PTX | CSF-1 | [85] |
Breast | +/DOX | PTEN | [211] | |
- 133a | HCC | −/DOX | ABCC1 | [52] |
- 134 | Lung | +/Gefitinib | MAGI2 | [212] |
- 135a/b | Lung | −/CDDP | Mcl-1 | [171] |
- 136 | Ovarian | −/PTX | Notch3 | [213] |
- 137 | Breast | −/DOX | YB-1 | [27] |
Multiple myeloma | −/Bortezomib, Eprirubicin | AURKA | [214] | |
- 138 | NSCLC | −/CDDP | ERCC1 | [59] |
NSCLC | −/Gefitinib | GPR124 | [69] | |
- 141 | Esophageal | +/CDDP | YAP1 | [215] |
HCC | +/5-FU | Keap1 | [53] | |
- 143 | Prostate | −/Docetaxel | KRAS | [101] |
- 145 | Ovarian | −/PTX | SP1, CDK6 | [216] |
- 148a | Prostate | −/PTX | MSK1 | [100] |
- 149 | Breast | −/DOX | NDST1 | [28] |
- 153 | Colorectal | +/L-OHP, CDDP | FOXO3a | [78] |
- 155 | Breast | +/DOX, VP-16, PTX | FOXO3a | [36] |
- 181a | Breast | −/DOX | BCL-2 | [32] |
Cervical | +/CDDP | PRKCD | [217] | |
- 181b | Lung | −/VCR, CDDP | BCL-2 | [109] |
- 182 | NSCLC | +/CDDP | PDCD4 | [60] |
HCC | +/CDDP | TP53INP1 | [44] | |
- 183 | Nasopharyngeal | −/CDDP | MTA1 | [218] |
- 190b | HCC | +/Insulin | IGF-1 | [219] |
- 193a-3p | HCC | +/5-FU | SRSF2 | [54] |
- 193b | HCC | −/Sorafenib | Mcl-1 | [48] |
- 195 | Breast | −/DOX | Raf-1 | [29] |
Colon | −/DOX | BCL2L2 | [165] | |
HCC | +/5-FU | BCL-w | [55] | |
Colon | −/5-FU | CHK1, WEE1 | [220] | |
- 197 | Ovarian | +/Taxol | NLK | [221] |
- 199a-3p | HCC | −/DOX | mTOR, c-Met | [173] |
- 199a-5p | HCC | −/CDDP | ATG7 | [47] |
- 199b-5p | Ovarian | −/CDDP | JAG1 | [86] |
- 200b | Prostate | −/Docetaxel | Bmi1 | [222] |
SCLC | −/CDDP,DOX,VP-16 | ZEB2 | [71] | |
Lung | −/Docetaxel | E2F3 | [70] | |
Gastric, Lung | −/VCR, CDDP | BCL-2, XIAP | [169] | |
- 200c | Gastric | −/CDDP | RhoE | [110] |
Breast | −/DOX | TrKB, Bmi1 | [223] | |
Ovarian | −/PTX | TuBB3, TrKB | [96] | |
Breast | −/Trastuzumab | ZNF217, ZEB1 | [224] | |
- 203 | Glioblastoma | −/Imatinib,VP-16,TMZ | SNAI2 | [225] |
Colorectal | +/L-OHP | ATM | [226] | |
Colorectal | −/5-FU | TYMS | [79] | |
Breast | +/CDDP | SOCS3 | [39] | |
- 205 | NSCLC | +/CDDP | PTEN | [61] |
- 214 | Cervical | −/CDDP | Bcl2l2 | [111] |
Ovarian | +/CDDP | PTEN | [156] | |
- 216a/217 | HCC | +/Sorafenib | PTEN, SMAD7 | [49] |
- 218 | Breast | −/GEM | BIRC5 | [227] |
Gallbladder | −/DOX, Taxol | PRKCE | [228] | |
- 221 | Breast | +/Trastuzumab | PTEN | [229] |
- 223 | HCC | −/DOX | ABCB1 | [51] |
Gastric | −/Trastuzumab | FBXW7 | [230] | |
- 224 | Lung | +/CDDP | P21(WAF1/CIP1) | [62] |
- 298 | Breast | −/DOX | MDR1 | [184] |
- 320 | Colon | −/5-FU, L-OHP | FOXM1 | [231] |
- 320a | Breast | −/DOX | TRPC5, NFATC3 | [33] |
- 320c | Pancreatic | +/GEM | SMARCC1 | [232] |
- 328 | Bresat | −/MX | ABCG2 | [185] |
- 337-3p | NSCLC | −/PTX | STAT3, RAP1A | [233] |
- 338-3p | HCC | −/Sorafenib | HIF-1α | [234] |
- 340 | HCC | −/CDDP | Nrf2 | [45] |
- 370 | Ovarian | −/CDDP | ENG | [84] |
- 375 | Breast | −/TAM | MTDH | [235] |
- 449a | Ovarian | −/CDDP | NOTCH1 | [87] |
- 451 | Colorectal | −/Irinotecan | COX-2 | [236] |
Breast | −/PTX | YWHAZ | [237] | |
- 452 | Breast | −/DOX | IGF-1R | [30] |
- 486 | CML | +/Imatinib | FOXO1, PTEN | [105] |
- 487a | Breast | −/MX | ABCG2 | [186] |
- 489 | Ovarian | −/CDDP | Akt3 | [31] |
Breast | −/DOX | Smad3 | [238] | |
- 491-3p | HCC | −/multidrug | ABCB1, SP3 | [239] |
- 497 | Colorectal | −/5-FU | Smurf1 | [240] |
- 503 | Lung | −/CDDP | BCL-2 | [166] |
Colorectal | +/L-OHP | PUMA | [241] | |
- 513a-3p | Lung | −/CDDP | GSTP1 | [66] |
- 519d | Breast | −/CDDP | MCL-1 | [242] |
- 591 | Ovarian | −/PTX | ZEB1 | [99] |
- 587 | Colorectal | +/5-FU | PPP2R1B | [243] |
- 650 | Lung | +/Docetaxel | ING4 | [40] |
- 663 | Breast | +/Docetaxel, Cyclophosphamide | HSPG2 | [244] |
- 1915 | Colorectal | −/L-OHP, DOX | BCL-2 | [80] |
- 3656 | Pancreatic | −/GEM | RHOF | [245] |