Table 1 Histone lysine demethylases (KDMs) and their selective inhibitors
From: Tackling malignant melanoma epigenetically: histone lysine methylation
| Â | Enzyme | Alias | Â | Structure | Inhibitor | Reference |
|---|---|---|---|---|---|---|
H3K4 | LSD1 | KDM1A | AOF2 | SWIRM/AOD | GSK2879552 Tranylcypromine (TCP) Compound S2101 T-3775440 NCD38 OG-L002 RN1 | |
JARID1A | KDM5A | RBP2 | PHD/ARID/ZF | Â | Â | |
JARID1B | KDM5B | PLU-1 | PHD/ARID/ZF | KDM5-C49 KDM5-C70 2,4-PDCA PBIT KDOAM-25 | ||
JARID1C | KDM5C | SMCX | PHD/ARID/ZF | Â | Â | |
JARID1D | KDM5D | SMCY | PHD/ARID/ZF | Â | Â | |
H3K9 | LSD1 | KDM1A | AOF2 | SWIRM/AOD | Â | Â |
JMJD1A | KDM3A | JHDM2A | JmjC | Â | Â | |
JMJD1B | KDM3B | JHDM2B | JmjC | Â | Â | |
JMJD2A | KDM4A | JHDM3A | PHD/Tudor | 2,4-PDCA | [14] | |
JMJD2B | KDM4B | JHDM3B | PHD/Tudor | Â | Â | |
JMJD2C | KDM4C | JHDM3C | PHD/Tudor | Â | Â | |
H3K27 | UTX | KDM6A | Â | TPR/JmjC | GSK-J1 GSK-J4 | |
JMJD3 | KDM6B | Â | JmjC | |||
H3K36 | FBXL11 | KDM2A | JHDM1A | PHD/ZF/LRR | Â | Â |
FBXL10 | KDM2B | JHDM1B | PHD/ZF/LRR | Â | Â | |
JMJD2A | KDM4A | JHDM3A | PHD/Tudor | Â | Â | |
JMJD2B | KDM4B | JHDM3B | PHD/Tudor | Â | Â | |
JMJD2C | KDM4C | JHDM3C | PHD/Tudor | Â | Â | |
H4K20 | LSD1n | Â | neuroLSD1 | Â | Â | Â |