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Table 1 Histone lysine demethylases (KDMs) and their selective inhibitors

From: Tackling malignant melanoma epigenetically: histone lysine methylation

  Enzyme Alias   Structure Inhibitor Reference
H3K4 LSD1 KDM1A AOF2 SWIRM/AOD GSK2879552 Tranylcypromine (TCP) Compound S2101 T-3775440 NCD38 OG-L002 RN1 [24,25,26,27]
JARID1A KDM5A RBP2 PHD/ARID/ZF   
JARID1B KDM5B PLU-1 PHD/ARID/ZF KDM5-C49 KDM5-C70 2,4-PDCA PBIT KDOAM-25 [13,14,15]
JARID1C KDM5C SMCX PHD/ARID/ZF   
JARID1D KDM5D SMCY PHD/ARID/ZF   
H3K9 LSD1 KDM1A AOF2 SWIRM/AOD   
JMJD1A KDM3A JHDM2A JmjC   
JMJD1B KDM3B JHDM2B JmjC   
JMJD2A KDM4A JHDM3A PHD/Tudor 2,4-PDCA [14]
JMJD2B KDM4B JHDM3B PHD/Tudor   
JMJD2C KDM4C JHDM3C PHD/Tudor   
H3K27 UTX KDM6A   TPR/JmjC GSK-J1 GSK-J4 [41, 42]
JMJD3 KDM6B   JmjC
H3K36 FBXL11 KDM2A JHDM1A PHD/ZF/LRR   
FBXL10 KDM2B JHDM1B PHD/ZF/LRR   
JMJD2A KDM4A JHDM3A PHD/Tudor   
JMJD2B KDM4B JHDM3B PHD/Tudor   
JMJD2C KDM4C JHDM3C PHD/Tudor   
H4K20 LSD1n   neuroLSD1