Methylome profiling of healthy and central precocious puberty girls

Clinical Epigenetics

Table 5 DMRs related to pubertal process in this study that were previously reported by Almstrup during transition to puberty

DMR	Chr	DMR start	DMR end	DMR width	Number of CpGs	Mean beta difference (pre-pubertal minus post-pubertal values)	Minimum FDR	Promoters of genes included in the DMR
DMR_10849*	7	100,463,206	100465221	2016	11	− 0.050845841	8.06E−11	TRIP6
DMR_10848*	7	100,449,647	100,450,634	988	8	− 0.011123245	8.92E−22	SLC12A9, RP11-126 L15.4
DMR_4835	17	7,834,607	7,835,519	913	13	− 0.004918456	2.27E−35	TRAPPC1, KCNAB3, CNTROB
DMR_5149	17	4,6687,312	46,692,859	5548	34	− 0.010869697	1.33E−51	HOXB8, HOXB7
DMR_6184	19	46,996,347	46,999,444	3098	15	− 0.017502407	1.01E−10	AC011484.1, PNMAL2
DMR_9947*	6	31,543,289	31,543,686	398	10	− 0.024464641	1.26944E−07	TNF
DMR_5887*	19	15,528,530	15,530,737	2208	18	− 0.007917542	1.19E−30	AKAP8L
DMR_1838*	11	2,925,594	2,927,247	1654	15	0.005243223	2.57836E−07	SLC22A18, SLC22A18AS
DMR_9898*	6	30,290,258	30,296,049	5792	57	− 0.014466232	3.04E−79	TRIM39, HCG18
DMR_2718*	12	52,626,427	52,627,576	1150	10	− 0.024084513	1.47E−20	KRT7

Abbreviations: Chr chromosome, DMR differentially methylated regions, FDR false discovery rate
*DMRs with methylation changes in the same direction

ISSN: 1868-7083