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Table 2 Comparison of % methylation changes in CF subjects at gene-specific CpGs: EPIC Δ-beta vs targeted NGS Δ-beta value

From: Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis

Gene

Location

EPIC

Δ-beta value

tNGS

Δ-beta value

CD6

cg26427109

(−) 0.42

(−) 0.344

HOOK2

cg11738485

(−) 0.32

(−) 0.32

LSP1

cg18723409

(−) 0.44

(−) 0.292

RGS12

cg03132824

(+) 0.40

(+) 0.291

SH3PXD2A

cg06888746

(−) 0.28

(−) 0.184

UPP1

cg10317717

(+) 0.24

(+) 0.263

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Clinical Epigenetics

ISSN: 1868-7083

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