Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma

Clinical Epigenetics

Table 1 The association of TMEM176A methylation and clinical factors in human HCC

Clinical factor	No.	TMEM176Amethylation status		P value
Clinical factor	No.	Unmethylated, n = 31 (24.6%)	Methylated, n = 95 (75.4%)	P value
Age (years)				0.769
< 60	88	21	67
≥ 60	38	10	28
Gender				0.798
Male	108	27	81
Female	18	4	14
HBV infection				0.948
Yes	90	22	68
No	36	9	27
Liver cirrhosis				0.955
Yes	93	23	70
No	33	8	25
Tumor size (cm)				0.242
> 5	84	18	66
≤ 5	42	13	29
Differentiation				0.029*
Well or moderate	68	22	46
Poor	58	9	49
TNM stage				0.377
Stage I + stage II	52	14	38
Stage III + stage IV	65	13	52
Number of lesions				0.347
1	98	26	72
≥ 1	28	5	23
Vessel cancerous embolus				0.599
Negative	93	24	69
Positive	33	7	26
Lymph node metastasis				0.644
Negative	120	30	90
Positive	6	1	5

ISSN: 1868-7083