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Table 1 The association of TMEM176A methylation and clinical factors in human HCC

From: Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma

Clinical factor No. TMEM176Amethylation status P value
Unmethylated, n = 31 (24.6%) Methylated, n = 95 (75.4%)
Age (years)     0.769
 < 60 88 21 67  
 ≥ 60 38 10 28  
Gender     0.798
 Male 108 27 81  
 Female 18 4 14  
HBV infection     0.948
 Yes 90 22 68  
 No 36 9 27  
Liver cirrhosis     0.955
 Yes 93 23 70  
 No 33 8 25  
Tumor size (cm)     0.242
 > 5 84 18 66  
 ≤ 5 42 13 29  
Differentiation     0.029*
 Well or moderate 68 22 46  
 Poor 58 9 49  
TNM stage     0.377
 Stage I + stage II 52 14 38  
 Stage III + stage IV 65 13 52  
Number of lesions     0.347
 1 98 26 72  
 ≥ 1 28 5 23  
Vessel cancerous embolus     0.599
 Negative 93 24 69  
 Positive 33 7 26  
Lymph node metastasis     0.644
 Negative 120 30 90  
 Positive 6 1 5  
  1. P values are obtained from chi-square test, significant difference
  2. *P < 0.05