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Fig. 3 | Clinical Epigenetics

Fig. 3

From: DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder

Fig. 3

The scatter plots describe the association between the mean percent change of PTSD symptoms and mean FKBP5 methylation dependent on child abuse in patients treated with GSK561679 (a, c) or placebo (b, d). Higher symptom percent change corresponds to improvement (reduction) in PTSD symptoms from baseline to endpoint. Abused patients are shown in red (solid line) and non-abused patients in blue (dashed line). The three-way interaction testing FKBP5 baseline methylation × treatment × child abuse on CAPS %-change had a p value of p = 0.099 with an n = 79 (c, d) and p > 0.05 with PSS %-change (n = 78) (a, b). After treatment stratification, there was no significant interaction effect of baseline methylation by child abuse on PTSD symptom %-change in neither one of the treatment groups (p > 0.05 for all) (ad)

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