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Table 2 Smoking differentially expressed genes in adipose tissue (42 smoking-DES)

From: Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

ID CHR Name Coef. S.E. P value cis eQTLs
ENSG00000140465.7 15 CYP1A1 1.899 0.103 5.37 × 10−51 rs35213055; 1.53 × 10−6
ENSG00000138061.7 2 CYP1B1 1.373 0.131 2.83 × 10−21  
ENSG00000144331.14 2 ZNF385B − 1.257 0.134 1.53 × 10−18 rs9288034; 8.33 × 10−5
ENSG00000179151.6 15 EDC3 1.167 0.129 3.10 × 10−17  
ENSG00000063438.12 5 AHRR 1.059 0.149 6.03 × 10−12  
ENSG00000175267.8 16 VWA3A 0.932 0.139 2.18 × 10−10  
ENSG00000170381.7 7 SEMA3E − 0.821 0.137 8.35 × 10−9 chr7:83264879;1.22 × 10−10
ENSG00000170891.6 4 CYTL1 0.807 0.142 2.82 × 10−8  
ENSG00000187486.5 11 KCNJ11 − 0.859 0.148 3.27 × 10−8  
ENSG00000168280.11 2 KIF5C − 0.813 0.145 4.74 × 10−8  
ENSG00000006016.5 19 CRLF1 0.769 0.146 2.53 × 10−7 chr19:18717389; 2.63 × 10−6
ENSG00000127533.2 19 F2RL3 0.782 0.147 2.89 × 10−7  
ENSG00000149294.11 11 NCAM1 − 0.715 0.135 3.03 × 10−7 rs17510563; 2.01 × 10−7
ENSG00000120693.9 13 SMAD9 − 0.733 0.140 4.76 × 10−7  
ENSG00000169116.7 4 PARM1 − 0.686 0.133 6.76 × 10−7  
ENSG00000154330.6 9 PGM5 − 0.716 0.147 1.72 × 10−6  
ENSG00000162430.12 1 SEPN1 − 0.663 0.137 1.82 × 10−6  
ENSG00000154721.9 21 JAM2 − 0.667 0.136 2.23 × 10−6  
ENSG00000177303.4 17 CASKIN2 − 0.669 0.140 2.90 × 10−6  
ENSG00000157404.10 4 KIT 0.708 0.150 3.31 × 10−6  
ENSG00000161544.4 17 CYGB 0.621 0.131 3.42 × 10−6  
ENSG00000154065.9 18 ANKRD29 − 0.684 0.144 3.49 × 10−6  
ENSG00000176907.3 8 C8orf4 − 0.714 0.151 3.56 × 10−6  
ENSG00000168032.4 3 ENTPD3 − 0.674 0.140 3.86 × 10−6 rs34158576; 7.60 × 10−6
ENSG00000162367.6 1 TAL1 − 0.665 0.142 4.17 × 10−6  
ENSG00000180785.8 11 OR51E1 − 0.655 0.142 6.82 × 10−6 rs11033126; 3.78 × 10−10
ENSG00000164010.9 1 ERMAP − 0.690 0.154 9.50 × 10−6  
ENSG00000068078.12 4 FGFR3 − 0.643 0.143 9.68 × 10−6 rs744658; 9.68 × 10−8
ENSG00000246223.4 14 C14orf64 − 0.633 0.142 1.44 × 10−5 rs75700090; 2.00 × 10−5
ENSG00000145506.9 5 NKD2 0.616 0.140 1.46 × 10−5  
ENSG00000161649.7 17 CD300LG − 0.648 0.147 1.48 × 10−5  
ENSG00000163873.5 1 GRIK3 − 0.643 0.146 1.50 × 10−5  
ENSG00000053747.9 18 LAMA3 − 0.652 0.148 1.57 × 10−5  
ENSG00000183733.6 2 FIGLA 0.406 0.093 1.57 × 10−5  
ENSG00000164736.5 8 SOX17 − 0.629 0.144 1.64 × 10−5  
ENSG00000106078.12 7 COBL − 0.680 0.155 1.65 × 10−5  
ENSG00000120156.14 9 TEK − 0.610 0.140 1.67 × 10−5  
ENSG00000178726.5 20 THBD − 0.612 0.141 2.00 × 10−5  
ENSG00000177675.4 12 CD163L1 0.635 0.148 2.40 × 10−5  
ENSG00000136828.13 9 RALPGS1 − 0.646 0.151 2.60 × 10−5  
ENSG00000135914.4 2 HTR2B 0.613 0.144 2.82 × 10−5  
ENSG00000090530.5 3 LEPREL1 − 0.617 0.145 2.86 × 10−5 rs6768989; 1.10 × 10−9
  1. ID, Ensemble ID; CHR, chromosome; Coef., regression coefficients from the linear mixed effect model, positive values reflect higher expression in current smokers and negative values represent lower expression in current smokers; eQTL, expression quantitative trait locus