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Table 2 Smoking differentially expressed genes in adipose tissue (42 smoking-DES)

From: Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

ID

CHR

Name

Coef.

S.E.

P value

cis eQTLs

ENSG00000140465.7

15

CYP1A1

1.899

0.103

5.37 × 10−51

rs35213055; 1.53 × 10−6

ENSG00000138061.7

2

CYP1B1

1.373

0.131

2.83 × 10−21

 

ENSG00000144331.14

2

ZNF385B

− 1.257

0.134

1.53 × 10−18

rs9288034; 8.33 × 10−5

ENSG00000179151.6

15

EDC3

1.167

0.129

3.10 × 10−17

 

ENSG00000063438.12

5

AHRR

1.059

0.149

6.03 × 10−12

 

ENSG00000175267.8

16

VWA3A

0.932

0.139

2.18 × 10−10

 

ENSG00000170381.7

7

SEMA3E

− 0.821

0.137

8.35 × 10−9

chr7:83264879;1.22 × 10−10

ENSG00000170891.6

4

CYTL1

0.807

0.142

2.82 × 10−8

 

ENSG00000187486.5

11

KCNJ11

− 0.859

0.148

3.27 × 10−8

 

ENSG00000168280.11

2

KIF5C

− 0.813

0.145

4.74 × 10−8

 

ENSG00000006016.5

19

CRLF1

0.769

0.146

2.53 × 10−7

chr19:18717389; 2.63 × 10−6

ENSG00000127533.2

19

F2RL3

0.782

0.147

2.89 × 10−7

 

ENSG00000149294.11

11

NCAM1

− 0.715

0.135

3.03 × 10−7

rs17510563; 2.01 × 10−7

ENSG00000120693.9

13

SMAD9

− 0.733

0.140

4.76 × 10−7

 

ENSG00000169116.7

4

PARM1

− 0.686

0.133

6.76 × 10−7

 

ENSG00000154330.6

9

PGM5

− 0.716

0.147

1.72 × 10−6

 

ENSG00000162430.12

1

SEPN1

− 0.663

0.137

1.82 × 10−6

 

ENSG00000154721.9

21

JAM2

− 0.667

0.136

2.23 × 10−6

 

ENSG00000177303.4

17

CASKIN2

− 0.669

0.140

2.90 × 10−6

 

ENSG00000157404.10

4

KIT

0.708

0.150

3.31 × 10−6

 

ENSG00000161544.4

17

CYGB

0.621

0.131

3.42 × 10−6

 

ENSG00000154065.9

18

ANKRD29

− 0.684

0.144

3.49 × 10−6

 

ENSG00000176907.3

8

C8orf4

− 0.714

0.151

3.56 × 10−6

 

ENSG00000168032.4

3

ENTPD3

− 0.674

0.140

3.86 × 10−6

rs34158576; 7.60 × 10−6

ENSG00000162367.6

1

TAL1

− 0.665

0.142

4.17 × 10−6

 

ENSG00000180785.8

11

OR51E1

− 0.655

0.142

6.82 × 10−6

rs11033126; 3.78 × 10−10

ENSG00000164010.9

1

ERMAP

− 0.690

0.154

9.50 × 10−6

 

ENSG00000068078.12

4

FGFR3

− 0.643

0.143

9.68 × 10−6

rs744658; 9.68 × 10−8

ENSG00000246223.4

14

C14orf64

− 0.633

0.142

1.44 × 10−5

rs75700090; 2.00 × 10−5

ENSG00000145506.9

5

NKD2

0.616

0.140

1.46 × 10−5

 

ENSG00000161649.7

17

CD300LG

− 0.648

0.147

1.48 × 10−5

 

ENSG00000163873.5

1

GRIK3

− 0.643

0.146

1.50 × 10−5

 

ENSG00000053747.9

18

LAMA3

− 0.652

0.148

1.57 × 10−5

 

ENSG00000183733.6

2

FIGLA

0.406

0.093

1.57 × 10−5

 

ENSG00000164736.5

8

SOX17

− 0.629

0.144

1.64 × 10−5

 

ENSG00000106078.12

7

COBL

− 0.680

0.155

1.65 × 10−5

 

ENSG00000120156.14

9

TEK

− 0.610

0.140

1.67 × 10−5

 

ENSG00000178726.5

20

THBD

− 0.612

0.141

2.00 × 10−5

 

ENSG00000177675.4

12

CD163L1

0.635

0.148

2.40 × 10−5

 

ENSG00000136828.13

9

RALPGS1

− 0.646

0.151

2.60 × 10−5

 

ENSG00000135914.4

2

HTR2B

0.613

0.144

2.82 × 10−5

 

ENSG00000090530.5

3

LEPREL1

− 0.617

0.145

2.86 × 10−5

rs6768989; 1.10 × 10−9

  1. ID, Ensemble ID; CHR, chromosome; Coef., regression coefficients from the linear mixed effect model, positive values reflect higher expression in current smokers and negative values represent lower expression in current smokers; eQTL, expression quantitative trait locus
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Clinical Epigenetics

ISSN: 1868-7083

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