Fig. 3

Smoking-associated DNA methylation and gene expression patterns at CYP1A1. a coMET plot [90] describing the genomic region of epigenome-wide association between smoking and CYP1A1 methylation (top panel), along with functional annotation of the region (middle panel), and pattern of co-methylation at the 34 CpG sites of CYP1A1 (bottom panel). b DNA methylation and gene expression changes with respect to smoking cessation. Methylation (at cg23680900) and gene expression levels are shown for five smoking status categories: current smokers (red); subjects who quit within 1 year, subjects who quit between 1 and 5 years, and subjects who quit over 5 years at the time of methylation sampling (gray); and non-smokers (blue). X-axis labels include the proportion of subjects who reverted in each smoking quit year category. c CYP1A1 methylation associations with adiposity phenotypes, visceral fat mass (VFM), and android-to-gynoid fat ratio (AGR). DNA methylation levels at three CpG sites (cg23160522, cg23680900, and cg10009577 in CYP1A1) are shown against adiposity phenotypes in current (red) and non-smokers (blue)