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Fig. 7 | Clinical Epigenetics

Fig. 7

From: Multiomics analyses identified epigenetic modulation of the S100A gene family in Kawasaki disease and their significant involvement in neutrophil transendothelial migration

Fig. 7

The expression variations of S100A family genes and methylation variations of the S100A-related CpG markers. a There were five, four, and one significant CpG markers (FDR < 0.05 and variation ratio > 1.1) located within the promoters of S100A8, S100A9, and S100A12, respectively. The locations of the ten CpG markers were indicated by the corresponding star signs. For each CpG marker, the Y axis of the box plot is the beta value (methylation percentage) determined with the M450K assays on 12 HC, 12 KD1, and 12 KD3 samples. b We used qPCR assays to detect gene expressions of S100A family genes on 24 HC, 21 FC, 17 KD1, and 18 KD3 samples. One KD1 sample failed the qPCR assay. The Y axis denoted the 2−ΔΔCt values. The data was presented as the average ± S.D. The values of the HC set were normalized to one. * and **** denoted p values < 0.05 and < 0.0001, respectively

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Clinical Epigenetics

ISSN: 1868-7083

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