|
Stage label
|
Relative change in geometric mean FGV (95% CI)
|
|---|
|
Model 1a
|
Model 2b
|
Model 3c
|
|---|
|
Tanner 2
|
|
Quartilesd
|
|
Q2
|
0.95 (0.80–1.12)
|
0.92 (0.77–1.10)
|
0.93 (0.77–1.11)
|
|
Q3
|
1.10 (0.92–1.31)
|
1.13 (0.94–1.37)
|
1.14 (0.95–1.37)
|
|
Q4
|
1.04 (0.88–1.25)
|
1.04 (0.87–1.24)
|
1.05 (0.88–1.27)
|
|
Linear modele
|
| |
1.02 (0.95–1.10)
|
1.01 (0.93–1.09)
|
1.01 (0.94–1.09)
|
|
Tanner 4
|
|
Quartilesd
|
|
Q2
|
0.91 (0.80–1.03)
|
0.94 (0.83–1.07)
|
0.94 (0.83–1.08)
|
|
Q3
|
0.99 (0.87–1.12)
|
0.98 (0.86–1.11)
|
0.99 (0.87–1.13)
|
|
Q4
|
0.94 (0.83–1.07)
|
0.92 (0.81–1.04)
|
0.92 (0.81–1.05)
|
|
Linear modele
|
| |
0.97 (0.92–1.03)
|
0.95 (0.90–1.01)
|
0.96 (0.90–1.01)
|
|
Tanner 2 (2 and 4)f
|
|
Quartilesd
|
|
Q2
|
0.93 (0.78–1.11)
|
0.92 (0.76–1.10)
|
0.92 (0.76–1.11)
|
|
Q3
|
1.14 (0.95–1.37)
|
1.20 (0.99–1.44)
|
1.20 (0.99–1.45)
|
|
Q4
|
1.02 (0.85–1.23)
|
1.05 (0.87–1.27)
|
1.05 (0.87–1.27)
|
|
Linear modele
|
| |
1.02 (0.94–1.10)
|
1.01 (0.93–1.10)
|
1.02 (0.93–1.11)
|
|
Tanner 4 (2 and 4)g
|
|
Quartilesd
|
|
Q2
|
0.90 (0.76–1.06)
|
0.90 (0.76–1.07)
|
0.90 (0.76–1.07)
|
|
Q3
|
1.07 (0.89–1.28)
|
1.05 (0.87–1.26)
|
1.05 (0.87–1.27)
|
|
Q4
|
0.91 (0.76–1.09)
|
0.81 (0.67–0.98)*
|
0.81 (0.67–0.98)*
|
|
Linear modele
|
| |
0.97 (0.90–1.05)
|
0.91 (0.83–0.99)*
|
0.91 (0.83–0.99)*
|
- aAssociation with mean ER-α methylation adjusting for fat percentage at breast density measurement
- bAssociation with cell composition corrected mean ER-α methylation adjusting for fat percentage at breast density measurement
- cModel 2 additionally adjusted for age at breast density measurement and maternal education
- dQuartiles for Tanner 2 methylation: Q1 [1.17, 4.05], Q2 (4.05, 6.04], Q3 (6.04, 8.85], Q4 (8.85, 29.30]; quartiles for Tanner 2 methylation after correction for cellular heterogeneity: Q1 [0.98, 3.49], Q2 (3.49, 5.03], Q3 (5.03, 7.34], Q4 (7.34, 24.8]. Quartiles for Tanner 4 methylation: Q1 [1.10, 4.27], Q2 (4.27, 7.05], Q3 (7.05, 9.37], Q4 (9.37, 32.00]; quartiles for Tanner 4 methylation after correction for cellular heterogeneity: Q1 [0.78, 3.37], Q2 (3.37, 5.28], Q3 (5.28, 6.96], Q4 (6.96, 23.60]
- eReporting relative change in geometric mean FGV per doubling of percent methylation
- fModeling B2 and B4 ER-α methylation simultaneously, reporting association with B2 ER-α methylation
- gModeling B2 and B4 ER-α methylation simultaneously, reporting association with B4 ER-α methylation
- *p<0.05, Wald test
