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Table 3 ER-α methylation at B4 is inversely associated with B4 FGV in Chilean girls enrolled in GOCS

From: Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls

Stage label Relative change in geometric mean FGV (95% CI)
Model 1a Model 2b Model 3c
Tanner 2
 Quartilesd
  Q2 0.95 (0.80–1.12) 0.92 (0.77–1.10) 0.93 (0.77–1.11)
  Q3 1.10 (0.92–1.31) 1.13 (0.94–1.37) 1.14 (0.95–1.37)
  Q4 1.04 (0.88–1.25) 1.04 (0.87–1.24) 1.05 (0.88–1.27)
 Linear modele
  1.02 (0.95–1.10) 1.01 (0.93–1.09) 1.01 (0.94–1.09)
Tanner 4
 Quartilesd
  Q2 0.91 (0.80–1.03) 0.94 (0.83–1.07) 0.94 (0.83–1.08)
  Q3 0.99 (0.87–1.12) 0.98 (0.86–1.11) 0.99 (0.87–1.13)
  Q4 0.94 (0.83–1.07) 0.92 (0.81–1.04) 0.92 (0.81–1.05)
 Linear modele
  0.97 (0.92–1.03) 0.95 (0.90–1.01) 0.96 (0.90–1.01)
Tanner 2 (2 and 4)f
 Quartilesd
  Q2 0.93 (0.78–1.11) 0.92 (0.76–1.10) 0.92 (0.76–1.11)
  Q3 1.14 (0.95–1.37) 1.20 (0.99–1.44) 1.20 (0.99–1.45)
  Q4 1.02 (0.85–1.23) 1.05 (0.87–1.27) 1.05 (0.87–1.27)
 Linear modele
  1.02 (0.94–1.10) 1.01 (0.93–1.10) 1.02 (0.93–1.11)
Tanner 4 (2 and 4)g
 Quartilesd
  Q2 0.90 (0.76–1.06) 0.90 (0.76–1.07) 0.90 (0.76–1.07)
  Q3 1.07 (0.89–1.28) 1.05 (0.87–1.26) 1.05 (0.87–1.27)
  Q4 0.91 (0.76–1.09) 0.81 (0.67–0.98)* 0.81 (0.67–0.98)*
 Linear modele
  0.97 (0.90–1.05) 0.91 (0.83–0.99)* 0.91 (0.83–0.99)*
  1. aAssociation with mean ER-α methylation adjusting for fat percentage at breast density measurement
  2. bAssociation with cell composition corrected mean ER-α methylation adjusting for fat percentage at breast density measurement
  3. cModel 2 additionally adjusted for age at breast density measurement and maternal education
  4. dQuartiles for Tanner 2 methylation: Q1 [1.17, 4.05], Q2 (4.05, 6.04], Q3 (6.04, 8.85], Q4 (8.85, 29.30]; quartiles for Tanner 2 methylation after correction for cellular heterogeneity: Q1 [0.98, 3.49], Q2 (3.49, 5.03], Q3 (5.03, 7.34], Q4 (7.34, 24.8]. Quartiles for Tanner 4 methylation: Q1 [1.10, 4.27], Q2 (4.27, 7.05], Q3 (7.05, 9.37], Q4 (9.37, 32.00]; quartiles for Tanner 4 methylation after correction for cellular heterogeneity: Q1 [0.78, 3.37], Q2 (3.37, 5.28], Q3 (5.28, 6.96], Q4 (6.96, 23.60]
  5. eReporting relative change in geometric mean FGV per doubling of percent methylation
  6. fModeling B2 and B4 ER-α methylation simultaneously, reporting association with B2 ER-α methylation
  7. gModeling B2 and B4 ER-α methylation simultaneously, reporting association with B4 ER-α methylation
  8. *p<0.05, Wald test
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