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Table 3 Correlations of DNA methylation levels with FADS1 and FADS2 gene expression

From: FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression

Region

CpG site

FADS1 mRNA levels

FADS2 mRNA levels

r

P 1

r

P 2

Region1

CpG_9

− 0.501

< 0.001

− 0.363

0.020

CpG_10

− 0.527

< 0.001

− 0.420

0.006

CpG_11

− 0.428

0.005

− 0.419

0.006

CpG_12

− 0.157

0.328

− 0.085

0.600

Region2

CpG_1

− 0.134

0.397

− 0.118

0.456

Region3

CpG_2

0.548

< 0.001

0.478

0.001

CpG_3

0.565

< 0.001

0.459

0.003

CpG_4

0.200

0.2062

0.235

0.135

  1. P1 and P2 separately indicate the correlation of DNA methylation of CpG site with FADS1 or FADS2 gene expression tested by Pearson’s correlation analysis. FADS fatty acid desaturase
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Clinical Epigenetics

ISSN: 1868-7083

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