Skip to main content

Table 1 Genes involved with distinct functions in breast cancer

From: Epigenetic regulation of ID4 in breast cancer: tumor suppressor or oncogene?

Gene symbol Gene name Molecular and cellular function
ABCB1 (MDR1) ATP-binding cassette subfamily B member 1 Xenobiotic transport
ABCG2 (BCRP) ATP-binding cassette subfamily G member 2 Xenobiotic transport
ADAM23 ADAM metallopeptidase domain 23 Proteolysis
AKT1 AKT serine/threonine kinase 1 Signal transduction (AKT and PI3 kinase signaling)
APC Adenomatosis polyposis coli Signal transduction (WNT signaling), cell adhesion, apoptosis, cell cycle, DNA damage, and repair
AR Androgen receptor Signal transduction (steroid receptor-mediated signaling) and transcription factor
ATM ATM serine/threonine kinase DNA damage and repair
BCL2 BCL2, apoptosis regulator Signal transduction (hedgehog signaling), cell adhesion, apoptosis, and cell cycle
BIRC5 Baculoviral IAP repeat-containing Signal transduction (Notch signaling)
BRCA1 Breast cancer 1 DNA damage and repair and signal transduction (steroid receptor-mediated signaling)
BRCA2 Breast cancer 2 DNA damage and repair
CCNA1 Cyclin A1 Cell cycle
CCND1 Cyclin D1 Cell cycle, DNA damage and repair, and signal transduction (hedgehog and WNT signaling)
CCND2 Cyclin D2 Cell cycle
CCNE1 Cyclin E1 Cell cycle and signal transduction (steroid receptor-mediated signaling)
CDH13 Cadherin 13 Cell adhesion and angiogenesis
CDK2 Cyclin-dependent kinase 2 Cell cycle
CDKN1A Cyclin-dependent kinase inhibitor 1A Cell cycle, DNA damage and repair, and apoptosis
CDKN1C Cyclin-dependent kinase inhibitor 1AC Cell cycle
CDKN2A Cyclin-dependent kinase inhibitor 2A Cell cycle, apoptosis, and cell adhesion
CST6 Cystatin E/M Proteases
CTNNB1 Catenin beta 1 Signal transduction (steroid receptor-mediated signaling), epithelial to mesenchymal transition, angiogenesis, and cell adhesion
CTSD Cathepsin D Proteases
EGF Epidermal growth factor Angiogenesis
ERBB2 Erb-b2 receptor tyrosine kinase 2 Signal transduction (AKT/PI3K signaling), angiogenesis, and cell adhesion
ESR1 Estrogen receptor 1 Signal transduction (steroid receptor-mediated signaling) and transcription factor
ESR2 Estrogen receptor 2 Signal transduction (steroid receptor-mediated signaling) and transcription factor
FOXA1 Forkhead box A1 Transcription factor
GATA3 GATA-binding protein 3 Transcription factor
HIC1 HIC ZBTB transcriptional repressor 1 Transcription factor
ID1 Inhibitor of DNA binding 1 Angiogenesis and breast cancer metastasis to lung and breast cancer classification marker
IGF1 Insulin-like growth factor 1 Signal transduction (steroid receptor-mediated and AKT/PI3K signaling)
IGF1R Insulin-like growth factor 1 receptor Signal transduction (AKT/PI3K signaling)
IGFBP3 Insulin-like growth factor-binding protein 3 Signal transduction (glucocorticoid signaling)
IL6 Interleukin 6 Angiogenesis and apoptosis
JUN Jun proto-oncogene Angiogenesis, apoptosis, cell cycle, and transcription factor
KRT19 Keratin 19 Signal transduction (steroid receptor-mediated signaling)
MAPK1 Mitogen-activated protein kinase 1 Signal transduction (MAP kinase-mediated signaling) and DNA damage and repair
MAPK3 Mitogen-activated protein kinase 3 Signal transduction (MAP kinase-mediated signaling)
MAPK8 Mitogen-activated protein kinase 8 Signal transduction (MAP kinase-mediated signaling)
MGMT O-6-methylguanine-DNA methyltransferase DNA damage and repair
MKI67 Marker of proliferation Ki-67 Cell cycle
MLH1 MutL homolog 1 DNA damage and repair
MMP2 Matrix metallopeptidase 2 Proteases and breast cancer metastasis to lung and breast cancer classification marker
MMP9 Matrix metallopeptidase 9 Proteases
MYC V-myc avian myelocytomatosis viral oncogene homolog Cell cycle and transcription factor
NME1 NME/NM23 nucleoside diphosphate kinase 1 Signal transduction (glucocorticoid signaling) and apoptosis
NOTCH1 Notch 1 Signal transduction (Notch signaling) and angiogenesis
NR3C1 Nuclear receptor subfamily 3 group C member 1 Signal transduction (glucocorticoid signaling) and transcription factor
PGR Progesterone receptor Signal transduction (steroid receptor-mediated signaling) and transcription factor
PLAU Plasminogen activator, urokinase Angiogenesis and proteases
PRDM2 PR/SET domain 2 Transcription factor
PTEN Phosphatase and tensin homolog Signal transduction (AKT/PI3K signaling), angiogenesis, cell adhesion, and cell cycle
PYCARD PYD and CARD domain-containing Proteases
RARB Retinoic acid receptor beta Apoptosis and transcription factor
RASSF1 Ras-association domain family member 1 Cell cycle
RB1 RB transcriptional corepressor 1 Signal transduction (steroid receptor-mediated signaling), cell cycle, and transcription factor
SERPINE1 Serpin family E member 1 Angiogenesis
SFN Stratifin Apoptosis, cell cycle, and DNA damage and repair
SFRP1 Secreted frizzled-related protein Signal transduction (WNT signaling) and apoptosis
SLIT2 Slit guidance ligand 2 Angiogenesis
THBS1 Thrombospondin 1 Angiogenesis and cell adhesion
TP53 Tumor protein p53 Apoptosis, cell cycle, DNA damage and repair, and transcription factor
TP73 Tumor protein p73 Apoptosis, DNA damage and repair, transcription factor, and signal transduction (MAP kinase signaling)
VEGFA Vascular endothelial growth factor Angiogenesis
XBP1 X-box binding protein 1 Transcription factor