Table 1 Genes involved with distinct functions in breast cancer
From: Epigenetic regulation of ID4 in breast cancer: tumor suppressor or oncogene?
Gene symbol | Gene name | Molecular and cellular function |
|---|---|---|
ABCB1 (MDR1) | ATP-binding cassette subfamily B member 1 | Xenobiotic transport |
ABCG2 (BCRP) | ATP-binding cassette subfamily G member 2 | Xenobiotic transport |
ADAM23 | ADAM metallopeptidase domain 23 | Proteolysis |
AKT1 | AKT serine/threonine kinase 1 | Signal transduction (AKT and PI3 kinase signaling) |
APC | Adenomatosis polyposis coli | Signal transduction (WNT signaling), cell adhesion, apoptosis, cell cycle, DNA damage, and repair |
AR | Androgen receptor | Signal transduction (steroid receptor-mediated signaling) and transcription factor |
ATM | ATM serine/threonine kinase | DNA damage and repair |
BCL2 | BCL2, apoptosis regulator | Signal transduction (hedgehog signaling), cell adhesion, apoptosis, and cell cycle |
BIRC5 | Baculoviral IAP repeat-containing | Signal transduction (Notch signaling) |
BRCA1 | Breast cancer 1 | DNA damage and repair and signal transduction (steroid receptor-mediated signaling) |
BRCA2 | Breast cancer 2 | DNA damage and repair |
CCNA1 | Cyclin A1 | Cell cycle |
CCND1 | Cyclin D1 | Cell cycle, DNA damage and repair, and signal transduction (hedgehog and WNT signaling) |
CCND2 | Cyclin D2 | Cell cycle |
CCNE1 | Cyclin E1 | Cell cycle and signal transduction (steroid receptor-mediated signaling) |
CDH13 | Cadherin 13 | Cell adhesion and angiogenesis |
CDK2 | Cyclin-dependent kinase 2 | Cell cycle |
CDKN1A | Cyclin-dependent kinase inhibitor 1A | Cell cycle, DNA damage and repair, and apoptosis |
CDKN1C | Cyclin-dependent kinase inhibitor 1AC | Cell cycle |
CDKN2A | Cyclin-dependent kinase inhibitor 2A | Cell cycle, apoptosis, and cell adhesion |
CST6 | Cystatin E/M | Proteases |
CTNNB1 | Catenin beta 1 | Signal transduction (steroid receptor-mediated signaling), epithelial to mesenchymal transition, angiogenesis, and cell adhesion |
CTSD | Cathepsin D | Proteases |
EGF | Epidermal growth factor | Angiogenesis |
ERBB2 | Erb-b2 receptor tyrosine kinase 2 | Signal transduction (AKT/PI3K signaling), angiogenesis, and cell adhesion |
ESR1 | Estrogen receptor 1 | Signal transduction (steroid receptor-mediated signaling) and transcription factor |
ESR2 | Estrogen receptor 2 | Signal transduction (steroid receptor-mediated signaling) and transcription factor |
FOXA1 | Forkhead box A1 | Transcription factor |
GATA3 | GATA-binding protein 3 | Transcription factor |
HIC1 | HIC ZBTB transcriptional repressor 1 | Transcription factor |
ID1 | Inhibitor of DNA binding 1 | Angiogenesis and breast cancer metastasis to lung and breast cancer classification marker |
IGF1 | Insulin-like growth factor 1 | Signal transduction (steroid receptor-mediated and AKT/PI3K signaling) |
IGF1R | Insulin-like growth factor 1 receptor | Signal transduction (AKT/PI3K signaling) |
IGFBP3 | Insulin-like growth factor-binding protein 3 | Signal transduction (glucocorticoid signaling) |
IL6 | Interleukin 6 | Angiogenesis and apoptosis |
JUN | Jun proto-oncogene | Angiogenesis, apoptosis, cell cycle, and transcription factor |
KRT19 | Keratin 19 | Signal transduction (steroid receptor-mediated signaling) |
MAPK1 | Mitogen-activated protein kinase 1 | Signal transduction (MAP kinase-mediated signaling) and DNA damage and repair |
MAPK3 | Mitogen-activated protein kinase 3 | Signal transduction (MAP kinase-mediated signaling) |
MAPK8 | Mitogen-activated protein kinase 8 | Signal transduction (MAP kinase-mediated signaling) |
MGMT | O-6-methylguanine-DNA methyltransferase | DNA damage and repair |
MKI67 | Marker of proliferation Ki-67 | Cell cycle |
MLH1 | MutL homolog 1 | DNA damage and repair |
MMP2 | Matrix metallopeptidase 2 | Proteases and breast cancer metastasis to lung and breast cancer classification marker |
MMP9 | Matrix metallopeptidase 9 | Proteases |
MYC | V-myc avian myelocytomatosis viral oncogene homolog | Cell cycle and transcription factor |
NME1 | NME/NM23 nucleoside diphosphate kinase 1 | Signal transduction (glucocorticoid signaling) and apoptosis |
NOTCH1 | Notch 1 | Signal transduction (Notch signaling) and angiogenesis |
NR3C1 | Nuclear receptor subfamily 3 group C member 1 | Signal transduction (glucocorticoid signaling) and transcription factor |
PGR | Progesterone receptor | Signal transduction (steroid receptor-mediated signaling) and transcription factor |
PLAU | Plasminogen activator, urokinase | Angiogenesis and proteases |
PRDM2 | PR/SET domain 2 | Transcription factor |
PTEN | Phosphatase and tensin homolog | Signal transduction (AKT/PI3K signaling), angiogenesis, cell adhesion, and cell cycle |
PYCARD | PYD and CARD domain-containing | Proteases |
RARB | Retinoic acid receptor beta | Apoptosis and transcription factor |
RASSF1 | Ras-association domain family member 1 | Cell cycle |
RB1 | RB transcriptional corepressor 1 | Signal transduction (steroid receptor-mediated signaling), cell cycle, and transcription factor |
SERPINE1 | Serpin family E member 1 | Angiogenesis |
SFN | Stratifin | Apoptosis, cell cycle, and DNA damage and repair |
SFRP1 | Secreted frizzled-related protein | Signal transduction (WNT signaling) and apoptosis |
SLIT2 | Slit guidance ligand 2 | Angiogenesis |
THBS1 | Thrombospondin 1 | Angiogenesis and cell adhesion |
TP53 | Tumor protein p53 | Apoptosis, cell cycle, DNA damage and repair, and transcription factor |
TP73 | Tumor protein p73 | Apoptosis, DNA damage and repair, transcription factor, and signal transduction (MAP kinase signaling) |
VEGFA | Vascular endothelial growth factor | Angiogenesis |
XBP1 | X-box binding protein 1 | Transcription factor |