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Table 2 Univariate Cox regression analysis of BCR-free survival for 5mC, 5hmC, 5fC, and 5caC score

From: Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer

Variable Full PC patient set ERG- PC patient subset ERG+ PC patient set
HR (95% CI) p value C-index HR (95% CI) p value C-index HR (95% CI) p value C-index
5mC score (cont.) 1.04 (0.72–1.50) 0.834 0.51 1.26 (0.69–2.28) 0.454 0.54 0.88 (0.54–1.43) 0.599 0.52
5mC score (dich.) 1.18 (0.85–1.62) 0.318 0.53 1.23 (0.76–2.00) 0.401 0.54 1.08 (0.70–1.69) 0.723 0.51
5hmC score (cont.) 1.37 (1.01–1.87) 0.045 0.55 1.62 (1.02–2.57) 0.043 0.59 1.14 (0.75–1.75) 0.537 0.51
5hmC score (dich.) 1.40 (1.02–1.92) 0.038 0.55 1.93 (1.19–3.14) 0.008 0.60 1.05 (0.69–1.61) 0.805 0.50
5fC score (cont.) 0.94 (0.73–1.20) 0.613 0.51 1.10 (0.78–1.56) 0.583 0.53 0.75 (0.52–1.09) 0.130 0.55
5fC score (dich.) 1.02 (0.67–1.56) 0.926 0.50 1.38 (0.77–2.49) 0.282 0.54 0.67 (0.34–1.33) 0.253 0.53
5caC score (cont.) 0.91 (0.73–1.14) 0.419 0.53 1.21 (0.86–1.71) 0.277 0.54 0.68 (0.51–0.92) 0.011 0.60
5caC score (dich.) 1.01 (0.73–1.40) 0.966 0.49 1.61 (0.98–2.63) 0.058 0.56 0.62 (0.40–0.97) 0.034 0.57
  1. Significant p values are highlighted in italics
  2. HR hazard ratio, CI confidence interval, C-index Harrell’s C-index