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Fig. 8 | Clinical Epigenetics

Fig. 8

From: TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells

Fig. 8

TET1 restored the expression of Wnt antagonists by demethylation of their promoter. a Dot-blot assay of 5-hmC and 5-mC in HNE1 and HONE1 cells with DNA concentration gradients. b The expression of target genes (DKKs, DACTs, SFRPs, and WNTs) in vector- and TET1-CD-transfected NPC cells was detected by qRT-PCR. c Methylation of DACTs, DKKs, SFRPs, and WNTs by MSP in vector- and TET1-transfected HNE1 and HONE1 cells. d The enrichment of 5-hmC and 5-mC in the promoter of Wnt5A, DACT2, and SFRP2 was detected by MeDIP-qPCR and hMeDIP-qPCR in HNE1 cells

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Clinical Epigenetics

ISSN: 1868-7083

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