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Table 3 Univariate and multivariate analyses of factors affecting DNAmAge and age acceleration residuals

From: Increased epigenetic age in normal breast tissue from luminal breast cancer patients

  Univariate analysis Multivariate analysis
Coef. Std. err. p > t Coef. Std. err. p > t
DNAmAge
Age 0.712 0.039 < 0.001 0.807 0.095 < 0.001
Breast cancer vs controls 6.551 2.78 0.021 4.489 1.663 0.009
 BMI 0.148 0.238 0.534 0.164 0.143 0.256
 Current alcohol use − 2.833 2.904 0.332
Smoking (py) 0.407 0.16 0.013 0.177 0.075 0.022
 Age at menarche 0.322 0.959 0.738 0.948 0.49 0.057
 Age at first live birth 0.03 0.251 0.905
 Count of live births
  1 2.292 5.494 0.678 − 4.92 3.268 0.137
  1+ 14.395 2.887 < 0.001 − 1.536 2.138 0.475
 Breast fed 5.286 2.83 0.065
 Post- vs pre-menopausal 18.645 2.138 < 0.001 − 3.982 3.006 0.19
 Hispanic − 5.924 5.018 0.241 − 3.921 3.223 0.228
 Race
  White − 0.059 5.815 0.992 0.709 3.088 0.819
  African Americans − 2.142 7.643 0.78 0.196 4.219 0.963
Age Acc. Residuals
 Age 0.000 0.039 1 0.095 0.095 0.324
Breast cancer vs controls 3.878 1.264 0.003 4.489 1.664 0.009
 BMI 0.117 0.11 0.288 0.164 0.143 0.256
 Current alcohol use − 2.484 1.349 0.068
Smoking (py) 0.174 0.074 0.022 0.178 0.076 0.022
 Age at menarche 0.358 0.454 0.433 0.949 0.491 0.057
 Age at first live birth − 0.169 0.153 0.274
 Count of live births
  1 − 1.598 2.9 0.583 − 4.92 3.268 0.137
  1+ 0.041 1.52 0.979 − 1.536 2.138 0.475
 Breast fed − 2.28 1.315 0.086
 Post vs pre-menopausal − 1.351 1.335 0.314 − 3.982 3.006 0.19
 Hispanic 0.636 2.342 0.786 − 3.921 3.223 0.228
Race
 White − 1.063 2.685 0.693 0.709 3.088 0.819
 African Americans 1.082 3.529 0.76 0.196 4.219 0.963
  1. Variables in italics are those which reached statistical significance