Table 3 Supplemental analysis: complete cases: adjusted regression of DNA methylation at birth and anthropometric z scores
BW/GA | WFL z scores 1 year | BMI z scores 3 years | ||||
|---|---|---|---|---|---|---|
Boys | Girls | Boys | Girls | Boys | Girls | |
β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | |
MEG3 | ||||||
Low | 0.46 (− 0.08, 0.10) | 0.23 (− 0.43, 0.85) | − 0.73 (− 1.56, 0.09) | 0.01 (− 0.69, 0.71) | − 0.22 (− 1.26, 0.83) | 0.24 (− 0.79, 1.27) |
High | 0.04 (− 0.53, 0.60) | − 0.02 (− 0.68, 0.63) | − 0.87 (− 1.73, 0.00) | 0.47 (− 0.25, 1.18) | − 0.10 (− 1.20, 0.99) | − 0.17 (− 1.22, 0.87) |
PLAGL1 | ||||||
Low | 0.20 (− 0.29, 0.70) | 0.30 (− 0.30, 0.89) | − 0.13 (− 0.89, 0.64) | − 0.46 (− 1.17, 0.25) | 0.07 (− 0.82, 0.97) | − 0.04 (− 1.01, 0.94) |
High | 0.26 (− 0.24, 0.76) | 0.13 (− 0.44, 0.71) | 0.22 (− 0.53, 0.97) | − 0.82* (− 1.51, − 0.12) | 0.82 (− 0.06, 1.70) | 0.05 (− 0.90, 1.00) |
PEG10 | ||||||
Low | − 0.35 (− 0.86, 0.16) | 0.40 (− 0.21, 1.00) | 0.06 (− 0.77, 0.88) | 0.11 (− 0.69, 0.90) | 0.53 (− 0.39, 1.46) | 0.54 (− 0.47, 1.56) |
High | 0.03 (− 0.44, 0.50) | 0.63* (0.07, 1.19) | 0.65 (− 0.12, 1.42) | 0.01 (− 0.73, 0.74) | 1.25* (0.38, 2.12) | 0.64 (− 0.31, 1.58) |
IGF2 | ||||||
Low | − 0.46 (− 1.02, 0.10) | 0.21 (− 0.37, 0.78) | − 0.51 (− 1.27, 0.25) | 0.30 (− 0.46, 1.06) | − 0.40 (− 1.35, 0.55) | 0.40 (− 0.58, 1.38) |
High | − 0.17 (− 0.70, 0.36) | 0.58* (0.03, 1.12) | − 0.02 (− 0.73, 0.68) | − 0.28 (− 0.99, 0.43) | − 0.36 (− 1.25, 0.53) | − 0.25 (− 1.17, 0.66) |
MEST | ||||||
Low | 0.41 (− 0.13, 0.95) | − 0.17 (− 0.85, 0.50) | 0.20 (− 0.58, 0.99) | − 1.18* (− 2.03, − 0.32) | 0.03 (− 0.98, 1.05) | − 0.36 (− 1.57, 0.86) |
High | − 0.05 (− 0.56, 0.47) | 0.62 (− 0.04, 1.28) | 0.38 (− 0.37, 1.12) | − 1.57** (− 2.41, − 0.74) | − 0.14 (− 1.11, 0.82) | − 1.09 (− 2.27, 0.08) |
MEG3-IG | ||||||
Low | − 0.10 (− 0.59, 0.39) | − 0.58 (− 1.30, 0.13) | − 0.22 (− 0.98, 0.55) | − 0.14 (− 1.03, 0.75) | − 0.60 (− 1.56, 0.36) | − 0.15 (− 1.08, 0.78) |
High | − 0.77* (− 1.29, − 0.24) | − 0.10 (− 0.77, 0.56) | − 0.70 (− 1.52, 0.12) | − 0.16 (− 0.98, 0.67) | − 0.19 (− 1.22, 0.83) | − 0.59 (− 1.46, 0.27) |
H19 | ||||||
Low | 0.21 (− 0.32, 0.73) | − 0.28 (− 0.86, 0.31) | − 0.001 (− 0.77, 0.77) | 0.24 (− 0.53, 1.01) | 0.53 (− 0.39, 1.46) | 0.06 (− 0.97, 1.06) |
High | 0.01 (− 0.52, 0.53) | 0.23 (− 0.33, 0.79) | − 0.001 (− 0.75, 0.75) | − 0.41 (− 1.13, 0.32) | 0.45 (− 0.45, 1.35) | − 0.08 (− 1.05, 0.89) |
NNAT | ||||||
Low | 0.07 (− 0.48, 0.61) | − 0.41 (− 1.02, 0.20) | − 0.89* (− 1.68, − 0.09) | 0.47 (− 0.18, 1.13) | − 0.59 (− 1.60, 0.42) | 1.12* (0.09, 2.15) |
High | − 0.26 (− 0.76, 0.24) | 0.39 (− 0.30, 1.08) | − 0.53 (− 1.27, 0.22) | 0.39 (− 0.34, 1.12) | − 0.31 (− 1.25, 0.63) | 0.24 (− 0.91, 1.38) |
PEG3 | ||||||
Low | 0.03 (− 0.52, 0.58) | 0.16 (− 0.46, 0.78) | − 0.22 (− 1.07, 0.62) | 0.00 (− 0.81, 0.81) | 0.46 (− 0.48, 1.40) | − 1.30* (− 2.34, − 0.25) |
High | 0.06 (− 0.54, 0.65) | 0.42 (− 0.20, 1.04) | − 0.26 (− 1.17, 0.66) | − 0.30 (− 1.12, 0.52) | − 0.31 (− 1.33, 0.71) | − 0.86 (− 1.91, 0.20) |