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Table 3 Supplemental analysis: complete cases: adjusted regression of DNA methylation at birth and anthropometric z scores

From: DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years

  BW/GA WFL z scores 1 year BMI z scores 3 years
Boys Girls Boys Girls Boys Girls
β (95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI)
MEG3
 Low 0.46 (− 0.08, 0.10) 0.23 (− 0.43, 0.85) − 0.73 (− 1.56, 0.09) 0.01 (− 0.69, 0.71) − 0.22 (− 1.26, 0.83) 0.24 (− 0.79, 1.27)
 High 0.04 (− 0.53, 0.60) − 0.02 (− 0.68, 0.63) − 0.87 (− 1.73, 0.00) 0.47 (− 0.25, 1.18) − 0.10 (− 1.20, 0.99) − 0.17 (− 1.22, 0.87)
PLAGL1
 Low 0.20 (− 0.29, 0.70) 0.30 (− 0.30, 0.89) − 0.13 (− 0.89, 0.64) − 0.46 (− 1.17, 0.25) 0.07 (− 0.82, 0.97) − 0.04 (− 1.01, 0.94)
 High 0.26 (− 0.24, 0.76) 0.13 (− 0.44, 0.71) 0.22 (− 0.53, 0.97) − 0.82* (− 1.51, − 0.12) 0.82 (− 0.06, 1.70) 0.05 (− 0.90, 1.00)
PEG10
 Low − 0.35 (− 0.86, 0.16) 0.40 (− 0.21, 1.00) 0.06 (− 0.77, 0.88) 0.11 (− 0.69, 0.90) 0.53 (− 0.39, 1.46) 0.54 (− 0.47, 1.56)
 High 0.03 (− 0.44, 0.50) 0.63* (0.07, 1.19) 0.65 (− 0.12, 1.42) 0.01 (− 0.73, 0.74) 1.25* (0.38, 2.12) 0.64 (− 0.31, 1.58)
IGF2
 Low − 0.46 (− 1.02, 0.10) 0.21 (− 0.37, 0.78) − 0.51 (− 1.27, 0.25) 0.30 (− 0.46, 1.06) − 0.40 (− 1.35, 0.55) 0.40 (− 0.58, 1.38)
 High − 0.17 (− 0.70, 0.36) 0.58* (0.03, 1.12) − 0.02 (− 0.73, 0.68) − 0.28 (− 0.99, 0.43) − 0.36 (− 1.25, 0.53) − 0.25 (− 1.17, 0.66)
MEST
 Low 0.41 (− 0.13, 0.95) − 0.17 (− 0.85, 0.50) 0.20 (− 0.58, 0.99) − 1.18* (− 2.03, − 0.32) 0.03 (− 0.98, 1.05) − 0.36 (− 1.57, 0.86)
 High − 0.05 (− 0.56, 0.47) 0.62 (− 0.04, 1.28) 0.38 (− 0.37, 1.12) − 1.57** (− 2.41, − 0.74) − 0.14 (− 1.11, 0.82) − 1.09 (− 2.27, 0.08)
MEG3-IG
 Low − 0.10 (− 0.59, 0.39) − 0.58 (− 1.30, 0.13) − 0.22 (− 0.98, 0.55) − 0.14 (− 1.03, 0.75) − 0.60 (− 1.56, 0.36) − 0.15 (− 1.08, 0.78)
 High − 0.77* (− 1.29, − 0.24) − 0.10 (− 0.77, 0.56) − 0.70 (− 1.52, 0.12) − 0.16 (− 0.98, 0.67) − 0.19 (− 1.22, 0.83) − 0.59 (− 1.46, 0.27)
H19
 Low 0.21 (− 0.32, 0.73) − 0.28 (− 0.86, 0.31) − 0.001 (− 0.77, 0.77) 0.24 (− 0.53, 1.01) 0.53 (− 0.39, 1.46) 0.06 (− 0.97, 1.06)
 High 0.01 (− 0.52, 0.53) 0.23 (− 0.33, 0.79) − 0.001 (− 0.75, 0.75) − 0.41 (− 1.13, 0.32) 0.45 (− 0.45, 1.35) − 0.08 (− 1.05, 0.89)
NNAT
 Low 0.07 (− 0.48, 0.61) − 0.41 (− 1.02, 0.20) − 0.89* (− 1.68, − 0.09) 0.47 (− 0.18, 1.13) − 0.59 (− 1.60, 0.42) 1.12* (0.09, 2.15)
 High − 0.26 (− 0.76, 0.24) 0.39 (− 0.30, 1.08) − 0.53 (− 1.27, 0.22) 0.39 (− 0.34, 1.12) − 0.31 (− 1.25, 0.63) 0.24 (− 0.91, 1.38)
PEG3
 Low 0.03 (− 0.52, 0.58) 0.16 (− 0.46, 0.78) − 0.22 (− 1.07, 0.62) 0.00 (− 0.81, 0.81) 0.46 (− 0.48, 1.40) − 1.30* (− 2.34, − 0.25)
 High 0.06 (− 0.54, 0.65) 0.42 (− 0.20, 1.04) − 0.26 (− 1.17, 0.66) − 0.30 (− 1.12, 0.52) − 0.31 (− 1.33, 0.71) − 0.86 (− 1.91, 0.20)
  1. Adjusted for maternal and paternal race, maternal education, maternal smoking, maternal pre-pregnancy BMI, maternal age, and gestational age. DNA methylation measured in tertiles, comparing low and high methylation to moderate methylation
  2. *p < 0.05. **Statistically significant after Bonferroni correction (p < 0.006)