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Fig. 5 | Clinical Epigenetics

Fig. 5

From: rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology

Fig. 5

Genotype-specific placental weight, birth weight (SD), and head circumference (SD) of controls, fresh embryo transfer (FRESH), and frozen embryo transfer (FET)-derived newborns. a Genotype-specific differences in birth weight of FRESH-derived newborns were observed (P = 0.04, one-way ANOVA): newborns with G/G in genotype were heavier compared to newborns with A/A (P = 0.04, Bonferroni post hoc). Birth weights (SD) of studied groups differ significantly in A/A genotype (P = 0.006, one-way ANOVA). FET-derived newborns are heavier compared to FRESH newborns (P = 0.004, Bonferroni post hoc). b Genotype-specific differences in head circumference of FRESH-derived newborns were observed (P = 0.004, one-way ANOVA): newborns with G/G genotype had larger head circumference compared to newborns with A/A (P = 0.002, Bonferroni post hoc). c Placental weights (g) differ significantly between the studied groups in A/A genotype (P = 0.024, One-way ANOVA). FET-derived placentas are heavier compared to FRESH (P = 0.02, Bonferroni post hoc). Error bars denote the SD. The numbers of samples are shown above the genotypes. Bonferroni post hoc test for one-way ANOVA: *P < 0.05, **P < 0.01, ***P ≤ 0.001

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