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Table 3 Univariate and multivariate analyses of prognostic factors for overall survival in non-APL-AML patients

From: H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia

  Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Age 2.294 (1.528–3.446) < 0.001 1.651 (1.067–2.555) 0.024
WBC 1.856 (1.247–2.764) 0.002 1.447 (0.943–2.220) 0.091
Karyotype classifications 1.756 (1.314–2.346) < 0.001 1.858 (1.320–2.616) < 0.001
H19 expression 1.486 (0.997–2.216) 0.052 1.554 (0.977–2.472) 0.063
CEBPA mutation 0.793 (0.410–1.533) 0.491   
NPM1 mutation 1.142 (0.606–2.152) 0.681   
FLT3-ITD mutation 1.005 (0.532–1.898) 0.987   
c-KIT mutation 1.043 (0.255–4.263) 0.953   
N/K-RAS mutation 1.070 (0.533–2.149) 0.849   
IDH1/2 mutation 4.246 (1.964–9.179) < 0.001 3.781 (1.593–8.978) 0.003
DNMT3A mutation 1.256 (0.630–2.506) 0.518   
U2AF1 mutation 2.756 (1.177–6.455) 0.020 2.499 (1.050–5.950) 0.038
SRSF2 mutation 2.005 (0.914–4.399) 0.083 1.590 (0.673–3.758) 0.291
SETBP1 mutation 0.497 (0.069–3.583) 0.488   
  1. Variables were composed of age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109/L), karyotype classifications (favorable vs. intermediate vs. poor), H19 expression (low vs. high), and gene mutations (mutant vs. wild-type). The multivariate analysis included variables with P < 0.100 in univariate analysis for overall survival
  2. AML acute myeloid leukemia, APL acute promyelocytic leukemia, WBC white blood cells, CI confidence interval