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Table 3 Univariate and multivariate analyses of prognostic factors for overall survival in non-APL-AML patients

From: H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia

 

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Age

2.294 (1.528–3.446)

< 0.001

1.651 (1.067–2.555)

0.024

WBC

1.856 (1.247–2.764)

0.002

1.447 (0.943–2.220)

0.091

Karyotype classifications

1.756 (1.314–2.346)

< 0.001

1.858 (1.320–2.616)

< 0.001

H19 expression

1.486 (0.997–2.216)

0.052

1.554 (0.977–2.472)

0.063

CEBPA mutation

0.793 (0.410–1.533)

0.491

  

NPM1 mutation

1.142 (0.606–2.152)

0.681

  

FLT3-ITD mutation

1.005 (0.532–1.898)

0.987

  

c-KIT mutation

1.043 (0.255–4.263)

0.953

  

N/K-RAS mutation

1.070 (0.533–2.149)

0.849

  

IDH1/2 mutation

4.246 (1.964–9.179)

< 0.001

3.781 (1.593–8.978)

0.003

DNMT3A mutation

1.256 (0.630–2.506)

0.518

  

U2AF1 mutation

2.756 (1.177–6.455)

0.020

2.499 (1.050–5.950)

0.038

SRSF2 mutation

2.005 (0.914–4.399)

0.083

1.590 (0.673–3.758)

0.291

SETBP1 mutation

0.497 (0.069–3.583)

0.488

  
  1. Variables were composed of age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109/L), karyotype classifications (favorable vs. intermediate vs. poor), H19 expression (low vs. high), and gene mutations (mutant vs. wild-type). The multivariate analysis included variables with P < 0.100 in univariate analysis for overall survival
  2. AML acute myeloid leukemia, APL acute promyelocytic leukemia, WBC white blood cells, CI confidence interval
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Clinical Epigenetics

ISSN: 1868-7083

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