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Fig. 5 | Clinical Epigenetics

Fig. 5

From: H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia

Fig. 5

The biological role of H19 on leukemic cell line HL60. a The underlying role of H19 in leukemogenesis determined by Coremine Medical online database (http://www.coremine.com/medical/). b H19 expression in eight common leukemic cell lines. The dotted line indicated the cutoff value to define H19 overexpression. c H19 expression mediated by siRNA-based H19 knockdown. H19 expression was significantly downregulated in siRNA-based H19 knockdown (siH19-1 and siH19-2) and control (siNC) groups. d The effect of H19 knockdown on cell proliferation. The siH19 groups (siH19-1 and siH19-2) showed significantly lower proliferation capacity than the siNC group at 48 and 72 h. e The effect of H19 knockdown on cell apoptosis. The siH19 groups (siH19-1 and siH19-2) showed significantly higher apoptosis rate than the siNC group at 48 h. fh Flow-type apoptosis figures for siNC, siH19-1, and siH19-2, respectively. *P < 0.05, **P < 0.01, ***P < 0.001

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