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Table 2 Top CpG methylation sites associated with metabolic syndrome status in HyperGEN discovery and REGARDS replication and meta-analysis in basic and adjusted models

From: Epigenome-wide association study of metabolic syndrome in African-American adults

Study Model CpG Chr Gene Location β (SE) p value
Discovery set
 HyperGEN (N = 614 (basic) and 606 (fully adjusted)) Basic cg06500161 21 ABCG1 43656587 0.017 (2.05 × 10− 3) 1.08 × 10−8
cg06638433 17 IGF2BP1 47075175 0.01 (1.90 × 10−3) 2.05 × 10−8
Fully adjusted cg06500161 21 ABCG1 43656587 0.018 (3.20 × 10−3) 2.60 × 10−8
cg06638433 17 IGF2BP1 47075175 0.01 (2.01 × 10−3) 3.10 × 10−7
Replication set
 REGARDS (N = 69) Basic cg06500161 21 ABCG1 43656587 0.029 (8.94 × 10−3) 0.001
  cg06638433 17 IGF2BP1 47075175 − 0.024 (0.012) 0.05
Fully adjusted cg06500161 21 ABCG1 43656587 0.032 (9.0 × 10−3) 4.7 × 10−4
   cg06638433 17 IGF2BP1 47075175 − 0.026 (0.012) 0.035
Meta-analysis
 HyperGEN and REGARDS Basic cg06500161 21 ABCG1 43656587 N/A 1.54 × 10−10
Fully adjusted cg06500161 21 ABCG1 43656587 N/A 2.15 × 10− 10
Basic cg06638433 17 IGF2BP1 47075175 N/A 1.29 × 10−7
Full adjusted cg06638433 17 IGF2BP1 47075175 N/A 1.55 × 10−6
  1. Basic models refer to linear mixed models with metabolic syndrome as a predictor and CpG β score as the outcome, adjusted for age, sex, center, first four principal components, and five estimated cell proportions. Full adjusted models were additionally adjusted for smoking and alcohol use. Meta-analysis p values are from Han and Eskin [22] random effects models