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Table 3 MTHFR 677TT and 1298CC genotypes in pregnancy complications

From: No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation

 

N

677TT frequency (N)

p value†

OR (95% CI)

1298CC frequency (N)

p value†

OR (95% CI)

Control

179

0.056 (10)

–

–

0.101 (18)

–

–

EOPE

28

0.107 (3)

0.249

2.02 (0.33–8.59)

0 (0)

1.00

0

LOPE

20

0.150 (3)

0.129

2.96 (0.48–13.1)

0.150 (3)

0.355

1.57 (0.27–6.27)

nIUGR

21

0.143 (3)

0.143

2.80 (0.45–12.3)

0.048 (1)

0.891

0.449 (0.01–3.16)

NTD

55

0.091 (5)

0.260

1.69 (0.43–5.72)

0.073 (4)

0.809

0.70 (0.16–2.27)

  1. OR odds ratio, CI confidence intervals, EOPE early-onset preeclampsia, LOPE late-onset preeclampsia, nIUGR normotensive intrauterine growth restriction, NTD neural tube defect
  2. †p values, calculated by one-tailed Fisher’s exact test
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Clinical Epigenetics

ISSN: 1868-7083

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