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Table 3 MTHFR 677TT and 1298CC genotypes in pregnancy complications

From: No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation

  N 677TT frequency (N) p value OR (95% CI) 1298CC frequency (N) p value OR (95% CI)
Control 179 0.056 (10) 0.101 (18)
EOPE 28 0.107 (3) 0.249 2.02 (0.33–8.59) 0 (0) 1.00 0
LOPE 20 0.150 (3) 0.129 2.96 (0.48–13.1) 0.150 (3) 0.355 1.57 (0.27–6.27)
nIUGR 21 0.143 (3) 0.143 2.80 (0.45–12.3) 0.048 (1) 0.891 0.449 (0.01–3.16)
NTD 55 0.091 (5) 0.260 1.69 (0.43–5.72) 0.073 (4) 0.809 0.70 (0.16–2.27)
  1. OR odds ratio, CI confidence intervals, EOPE early-onset preeclampsia, LOPE late-onset preeclampsia, nIUGR normotensive intrauterine growth restriction, NTD neural tube defect
  2. p values, calculated by one-tailed Fisher’s exact test