Table 2 Cox’s proportional hazard regression analysis of risk factors for overall survival in relapse patients

CIMP (−/+)

(42/95)

CIMP+

1.81 (1.04–3.16) (*p = 0.036)

Sex (male/female)

(79/58)

Sex = female

0.95 (0.56–1.60)

Age at primary diagnosis (years)

(137)

1.04 (0.97–1.10)

Initial risk group at primary diagnosis (SR/IR and HR)

(87/50)

Risk group = SR/IR

0.96 (0.53–1.76)

HSCT after relapse (no/yes)

(79/58)

HSCT = no

0.55 (0.32–0.97) (*p = 0.040)

IntReALL risk class (relapse site/time to relapse (SR/HR))

(88/49)

Risk group = SR

3.79 (1.98–7.29) (*p < 0.001)