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Table 2 Top 20 significantly differentially methylated sites in transcriptional cluster 3 placentas (N = 5) compared to transcriptional cluster 1 placentas (N = 19), corrected for fetal sex and gestational age at delivery

From: Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia

Probe Delta M Average M Delta β Average β FDR q value Gene(s) Location(s)a Enhancer Groupb
cg22131172 0.79 −3.59 0.04 0.08 1.58E-02 C13orf29 LINC00346 TSS1500-open sea TSS1500-open sea False Yes
cg24079702 0.50 −5.87 0.01 0.02 1.94E-02 FHL2 TSS200-island False No
cg10959820 0.75 −3.98 0.03 0.06 1.94E-02 RGS12 IGR-shelf True No
cg10319331 0.63 −3.84 0.02 0.07 1.94E-02 TMEM132B Body-open sea False No
cg05929019 −0.80 −2.79 −0.05 0.13 1.94E-02 LAMC2 TSS200-open sea False No
cg22790835 0.60 −2.93 0.04 0.12 1.94E-02 C13orf29 LINC00346 TSS1500-open sea TSS1500-open sea False Yes
cg14557185 0.78 −5.55 0.01 0.02 1.94E-02 WWTR1 Body-island False Yes
cg00296578 0.74 −3.60 0.04 0.08 1.94E-02 CRIM1 Body-open sea True No
cg21834463 −0.47 3.31 −0.03 0.91 1.94E-02 SGK1 Body-open sea True No
cg12634306 1.44 −4.70 0.05 0.04 1.94E-02 HEYL Body-open sea True No
cg22342100 0.83 −4.06 0.03 0.06 1.94E-02 KLHL38 TSS1500-open sea False No
cg27570256 −0.67 1.50 −0.10 0.74 1.94E-02 LOC100270710 TSS200-shelf True No
cg24741430 0.66 −3.09 0.05 0.11 1.94E-02 SMAD6 IGR-open sea True No
cg04082512 −0.43 0.77 −0.07 0.63 1.94E-02 GSE1 IGR-open sea True No
cg19458020 0.89 −4.52 0.03 0.04 2.14E-02 RARA TSS1500-island True No
cg25892587 0.67 −3.41 0.04 0.09 2.14E-02 KLF6 IGR-open sea True No
cg07605236c −1.22 2.60 −0.11 0.85 2.14E-02 SFXN5 TSS1500-shore False No
cg19478410 −0.61 2.34 −0.07 0.83 2.16E-02 SYT13 IGR-open sea False No
cg13250752 0.57 −1.98 0.06 0.20 2.16E-02 PCDH18 IGR-open sea True No
cg20669292 −1.03 3.93 −0.05 0.94 2.16E-02 PLEKHH3 Body-island True No
  1. aTSS transcription start site, IGR intergenic region
  2. bIncluded in a group of at least three significantly differentially methylated positions within the span of 1000 base pairs
  3. cAlso significantly differentially methylated in cluster 2 compared to cluster 1