Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia

Clinical Epigenetics

Table 2 Top 20 significantly differentially methylated sites in transcriptional cluster 3 placentas (N = 5) compared to transcriptional cluster 1 placentas (N = 19), corrected for fetal sex and gestational age at delivery

Probe	Delta M	Average M	Delta β	Average β	FDR q value	Gene(s)	Location(s)^a	Enhancer	Group^b
cg22131172	0.79	−3.59	0.04	0.08	1.58E-02	C13orf29 LINC00346	TSS1500-open sea TSS1500-open sea	False	Yes
cg24079702	0.50	−5.87	0.01	0.02	1.94E-02	FHL2	TSS200-island	False	No
cg10959820	0.75	−3.98	0.03	0.06	1.94E-02	RGS12	IGR-shelf	True	No
cg10319331	0.63	−3.84	0.02	0.07	1.94E-02	TMEM132B	Body-open sea	False	No
cg05929019	−0.80	−2.79	−0.05	0.13	1.94E-02	LAMC2	TSS200-open sea	False	No
cg22790835	0.60	−2.93	0.04	0.12	1.94E-02	C13orf29 LINC00346	TSS1500-open sea TSS1500-open sea	False	Yes
cg14557185	0.78	−5.55	0.01	0.02	1.94E-02	WWTR1	Body-island	False	Yes
cg00296578	0.74	−3.60	0.04	0.08	1.94E-02	CRIM1	Body-open sea	True	No
cg21834463	−0.47	3.31	−0.03	0.91	1.94E-02	SGK1	Body-open sea	True	No
cg12634306	1.44	−4.70	0.05	0.04	1.94E-02	HEYL	Body-open sea	True	No
cg22342100	0.83	−4.06	0.03	0.06	1.94E-02	KLHL38	TSS1500-open sea	False	No
cg27570256	−0.67	1.50	−0.10	0.74	1.94E-02	LOC100270710	TSS200-shelf	True	No
cg24741430	0.66	−3.09	0.05	0.11	1.94E-02	SMAD6	IGR-open sea	True	No
cg04082512	−0.43	0.77	−0.07	0.63	1.94E-02	GSE1	IGR-open sea	True	No
cg19458020	0.89	−4.52	0.03	0.04	2.14E-02	RARA	TSS1500-island	True	No
cg25892587	0.67	−3.41	0.04	0.09	2.14E-02	KLF6	IGR-open sea	True	No
cg07605236^c	−1.22	2.60	−0.11	0.85	2.14E-02	SFXN5	TSS1500-shore	False	No
cg19478410	−0.61	2.34	−0.07	0.83	2.16E-02	SYT13	IGR-open sea	False	No
cg13250752	0.57	−1.98	0.06	0.20	2.16E-02	PCDH18	IGR-open sea	True	No
cg20669292	−1.03	3.93	−0.05	0.94	2.16E-02	PLEKHH3	Body-island	True	No

^aTSS transcription start site, IGR intergenic region
^bIncluded in a group of at least three significantly differentially methylated positions within the span of 1000 base pairs
^cAlso significantly differentially methylated in cluster 2 compared to cluster 1

ISSN: 1868-7083