Skip to main content


Fig. 2 | Clinical Epigenetics

Fig. 2

From: Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer

Fig. 2

Different distributions of methylation and hydroxymethylation. a, b Principal component (PC) analysis based on methylation and hydroxymethylation levels for 0.5-kb tiles across 6 normal and tumor tissue samples. Coloring indicates classification of samples into subgroups. The red area denotes tumor tissues and the green area means normal tissue. c A large number of regions of differential hydroxymethylation (DhMRs) and methylation (DMRs) occur in colorectal cancer. Regions that gain a mark (“hyper-”) are represented by blue bars, whereas losses (“hypo-”) are red. d Visualization of DMRs (left) and DhMRs (right) patterns across all normal and tumor tissues (blue and red bars in the box). Boxed regions with green are candidate DMRs or DhMRs

Back to article page