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Table 6 Clinicopathological parameters in relation to RBBP8 promoter methylation in BLCA associated urine samples

From: Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

  RBBP8 promoter methylationb
  n a Low High p valuec
Parameter:
 Gender
  Male 42 31 11 0.687
  Female 10 8 2
 Histological tumor grade
  Low grade 19 17 2 0.046
  High grade 30 19 11
 Tumor stage
  pTa 21 19 2 0.021
  pT1-pT4 28 17 11
 pN status
  Negative 5 3 2 0.931
  Positive 8 5 3
  1. Significant p values are in italics
  2. aOnly patients with primary bladder cancer were included
  3. bRBBP8 methylation was dichotomized at the Q75 (based on pyrosequencing)
  4. cFisher’s exact test