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Table 6 Clinicopathological parameters in relation to RBBP8 promoter methylation in BLCA associated urine samples

From: Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

 

RBBP8 promoter methylationb

 

n a

Low

High

p valuec

Parameter:

 Gender

  Male

42

31

11

0.687

  Female

10

8

2

 Histological tumor grade

  Low grade

19

17

2

0.046

  High grade

30

19

11

 Tumor stage

  pTa

21

19

2

0.021

  pT1-pT4

28

17

11

 pN status

  Negative

5

3

2

0.931

  Positive

8

5

3

  1. Significant p values are in italics
  2. aOnly patients with primary bladder cancer were included
  3. bRBBP8 methylation was dichotomized at the Q75 (based on pyrosequencing)
  4. cFisher’s exact test
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Clinical Epigenetics

ISSN: 1868-7083

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