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Table 4 Clinicopathological parameters in relation to nuclear RBBP8 protein expression

From: Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

  RBBP8 IRSb nuclear  
  n a Low High p valuec Spearman r
Parameter:
 Age at diagnosis
  < 70 years 23 14 9 0.213 − 0.195
  ≥ 70 years 19 15 4
 Gender
  Male 33 25 8 0.075 − 0.278
  Female 9 4 5
 Tumor subtype
  Non-invasive papillary 17 8 9 0.012 − 0.392
  Invasive 25 21 4
 Histological tumor graded
  Low grade 12 4 8 0.002 − 0.489
  High grade 30 25 5
 Tumor staged
  pT1-pT2 13 9 4 0.040 − 0.419
  pT3-pT4 12 12 0
 RBBP8 methylation
  Low 11 5 6 0.020 − 0.564
  High 7 7 0
  1. Significant p values are in italics
  2. aOnly patients with primary bladder cancer were included
  3. bScore (IRS) according to Remmele and Stegner [42]
  4. cFisher’s exact test
  5. dAccording to WHO 2004 classification