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Table 4 Clinicopathological parameters in relation to nuclear RBBP8 protein expression

From: Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

 

RBBP8 IRSb nuclear

 
 

n a

Low

High

p valuec

Spearman r

Parameter:

 Age at diagnosis

  < 70 years

23

14

9

0.213

− 0.195

  ≥ 70 years

19

15

4

 Gender

  Male

33

25

8

0.075

− 0.278

  Female

9

4

5

 Tumor subtype

  Non-invasive papillary

17

8

9

0.012

− 0.392

  Invasive

25

21

4

 Histological tumor graded

  Low grade

12

4

8

0.002

− 0.489

  High grade

30

25

5

 Tumor staged

  pT1-pT2

13

9

4

0.040

− 0.419

  pT3-pT4

12

12

0

 RBBP8 methylation

  Low

11

5

6

0.020

− 0.564

  High

7

7

0

  1. Significant p values are in italics
  2. aOnly patients with primary bladder cancer were included
  3. bScore (IRS) according to Remmele and Stegner [42]
  4. cFisher’s exact test
  5. dAccording to WHO 2004 classification
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Clinical Epigenetics

ISSN: 1868-7083

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