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Table 3 Univariate analysis of clinicopathological parameters influencing OS

From: Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

  Overall survival (OS)
  n a Events p valueb
Parameter:
 RBBP8 methylationc
  RBBP8 Mlow 262 103 0.039
  RBBP8 Mhigh 85 24
 Gender
  Male 253 91 0.920
  Female 94 36
 Histological tumor graded
  Low grade 15 0 0.066
  High grade 329 127
 Tumor stage
  pT1-pT2 105 23 ≤ 0.001
  pT3-pT4 214 94
 pN status
  Negative 207 53 ≤ 0.001
  Nositive 111 63
 pM status
  Negative 168 52 0.004
  Positive 7 5
  1. Significant p values are in italics
  2. aOnly patients with primary bladder cancer without any neoadjuvant therapy were included
  3. bLog-rank test at the two-sided significance level of 0.05