Clinical Epigenetics

Table 3 Univariate analysis of clinicopathological parameters influencing OS

From: Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

	Overall survival (OS)
	n ^a	Events	p value^b
Parameter:
RBBP8 methylation^c
RBBP8 M^low	262	103	0.039
RBBP8 M^high	85	24	0.039
Gender
Male	253	91	0.920
Female	94	36	0.920
Histological tumor grade^d
Low grade	15	0	0.066
High grade	329	127	0.066
Tumor stage
pT1-pT2	105	23	≤ 0.001
pT3-pT4	214	94	≤ 0.001
pN status
Negative	207	53	≤ 0.001
Nositive	111	63	≤ 0.001
pM status
Negative	168	52	0.004
Positive	7	5	0.004

Significant p values are in italics
^aOnly patients with primary bladder cancer without any neoadjuvant therapy were included
^bLog-rank test at the two-sided significance level of 0.05

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