Fig. 2

Differential methylation after training is enriched at transcription start sites. a, b Median methylation levels for each cluster at non-DMR regions (a) compared to DMR regions (b). c, d Distribution of annotations comparing non-DMRs and DMRs on a percent scale. Visualized are both the Untrained/Trained (Trained, c) and Untrained/Detrained (Detrained, d) comparisons. Relative enrichment is visualized by the difference in bar height between DMRs and non-DMRs. e, f Density of transcription start sites (TSS) distances for DMRs and non-DMRs for the Untrained/Trained (Trained, e) and Untrained/Detrained (Detrained, f) comparisons. The DMRs come from a different distribution than the non-DMRs, as shown by a Kolmogorov–Smirnov test (P value on the plots)